Is fibrinogen determination by prothrombine time derived method confidant?
Elevated plasma fibrinogen (Fbg) levels have been shown, to be a risk factor for thrombotic events and cardiovascular disease. Currently, Fbg concentration is measured by Clauss and the prothrombine-time derived method. Despite of the derived method is simple and rapid, several studies have suggeste...
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paper:paper_03252957_v36_n3_p329_Lauricella2023-06-08T15:32:16Z Is fibrinogen determination by prothrombine time derived method confidant? Lauricella, Ana María Duboscq, Cristina Castañon, María Mercedes Kordich, Lucía Clelia Automated method Clauss method Fibrinogen Prothrombine time test fibrinogen heparin prothrombin accuracy article cardiovascular disease concentration response correlation analysis evaluation heparinization linear regression analysis median test protein blood level protein determination prothrombin time risk factor sampling technique thrombosis Elevated plasma fibrinogen (Fbg) levels have been shown, to be a risk factor for thrombotic events and cardiovascular disease. Currently, Fbg concentration is measured by Clauss and the prothrombine-time derived method. Despite of the derived method is simple and rapid, several studies have suggested that this technique would provide higher Fbg values than the real ones. In order to evaluate the accuracy of this method, the results were compared to those obtained by Clauss method (Bland-Altman procedure and Median test). Moreover, it was studied the heparine effect (0.2 to 0.6 UI/ml) on the Fbg levels determinated by prothrombine-time method (linear regression and Pearson correlation). The comparison between Fbg values obtained by Clauss and prothrombine-time derived methods, shows that results from both techniques are equivalent in the normal range. However, at Fbg values higher than 400 mg/dl another method, like Clauss, would be used. The results obtained by prothrombine-time derived method were not modified with heparinized samples in the therapeutic range. Fil:Lauricella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Duboscq, C.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Castañon, M.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kordich, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2002 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v36_n3_p329_Lauricella http://hdl.handle.net/20.500.12110/paper_03252957_v36_n3_p329_Lauricella |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Automated method Clauss method Fibrinogen Prothrombine time test fibrinogen heparin prothrombin accuracy article cardiovascular disease concentration response correlation analysis evaluation heparinization linear regression analysis median test protein blood level protein determination prothrombin time risk factor sampling technique thrombosis |
spellingShingle |
Automated method Clauss method Fibrinogen Prothrombine time test fibrinogen heparin prothrombin accuracy article cardiovascular disease concentration response correlation analysis evaluation heparinization linear regression analysis median test protein blood level protein determination prothrombin time risk factor sampling technique thrombosis Lauricella, Ana María Duboscq, Cristina Castañon, María Mercedes Kordich, Lucía Clelia Is fibrinogen determination by prothrombine time derived method confidant? |
topic_facet |
Automated method Clauss method Fibrinogen Prothrombine time test fibrinogen heparin prothrombin accuracy article cardiovascular disease concentration response correlation analysis evaluation heparinization linear regression analysis median test protein blood level protein determination prothrombin time risk factor sampling technique thrombosis |
description |
Elevated plasma fibrinogen (Fbg) levels have been shown, to be a risk factor for thrombotic events and cardiovascular disease. Currently, Fbg concentration is measured by Clauss and the prothrombine-time derived method. Despite of the derived method is simple and rapid, several studies have suggested that this technique would provide higher Fbg values than the real ones. In order to evaluate the accuracy of this method, the results were compared to those obtained by Clauss method (Bland-Altman procedure and Median test). Moreover, it was studied the heparine effect (0.2 to 0.6 UI/ml) on the Fbg levels determinated by prothrombine-time method (linear regression and Pearson correlation). The comparison between Fbg values obtained by Clauss and prothrombine-time derived methods, shows that results from both techniques are equivalent in the normal range. However, at Fbg values higher than 400 mg/dl another method, like Clauss, would be used. The results obtained by prothrombine-time derived method were not modified with heparinized samples in the therapeutic range. |
author |
Lauricella, Ana María Duboscq, Cristina Castañon, María Mercedes Kordich, Lucía Clelia |
author_facet |
Lauricella, Ana María Duboscq, Cristina Castañon, María Mercedes Kordich, Lucía Clelia |
author_sort |
Lauricella, Ana María |
title |
Is fibrinogen determination by prothrombine time derived method confidant? |
title_short |
Is fibrinogen determination by prothrombine time derived method confidant? |
title_full |
Is fibrinogen determination by prothrombine time derived method confidant? |
title_fullStr |
Is fibrinogen determination by prothrombine time derived method confidant? |
title_full_unstemmed |
Is fibrinogen determination by prothrombine time derived method confidant? |
title_sort |
is fibrinogen determination by prothrombine time derived method confidant? |
publishDate |
2002 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03252957_v36_n3_p329_Lauricella http://hdl.handle.net/20.500.12110/paper_03252957_v36_n3_p329_Lauricella |
work_keys_str_mv |
AT lauricellaanamaria isfibrinogendeterminationbyprothrombinetimederivedmethodconfidant AT duboscqcristina isfibrinogendeterminationbyprothrombinetimederivedmethodconfidant AT castanonmariamercedes isfibrinogendeterminationbyprothrombinetimederivedmethodconfidant AT kordichluciaclelia isfibrinogendeterminationbyprothrombinetimederivedmethodconfidant |
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1768542841729974272 |