Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis

Chemically induced and spontaneous liver tumors share some metabolic alterations. The decline in hemoprotein levels during hepatocarcinogenesis may result from a diminution of the intracellular heme pool. To elucidate if the onset of the pre-initiation stage alters the natural regulation mechanism o...

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Detalles Bibliográficos
Autores principales:	Vázquez, Elba Susana, Gerez, Esther Noemí, Batlle, Alcira María del Carmen
Publicado:	1999
Materias:	δ-Aminolevulinic acid synthase 2-allylisopropyl-acetamide Cytochrome P-450 Gluthatione S-transferase Hepatocarcinogenesis Microsomal heme oxygenase 4 dimethylaminoazobenzene 5 aminolevulinate synthase allylisopropylacetamide beta glucuronidase carcinogen cytochrome P450 enzyme inhibitor glutathione transferase heme heme oxygenase hemoprotein prodrug sulfatase tryptophan 2,3 dioxygenase animal article biological model biotransformation cell transformation chemically induced disorder comparative study drug antagonism drug effect drug resistance enzyme induction enzymology liver microsome liver tumor male metabolism mouse oxidation reduction reaction physiology precancer 5-Aminolevulinate Synthetase Allylisopropylacetamide Animals Biotransformation Carcinogens Cell Transformation, Neoplastic Cytochrome P-450 Enzyme System Drug Resistance Enzyme Induction Enzyme Inhibitors Glucuronidase Glutathione Transferase Heme Heme Oxygenase (Decyclizing) Hemeproteins Liver Neoplasms, Experimental Male Mice Microsomes, Liver Models, Biological Oxidation-Reduction p-Dimethylaminoazobenzene Precancerous Conditions Prodrugs Sulfatases Tryptophan Oxygenase
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03057232_v17_n1-2_p25_Vazquez http://hdl.handle.net/20.500.12110/paper_03057232_v17_n1-2_p25_Vazquez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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