Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients

Interferon-gamma (IFN-γ) production by peripheral blood mononuclear cells (PBMC) in 14 patients with anorexia nervosa (AN) was significantly lower than in 14 age-matched healthy controls. Follow-up samples in four patients displayed low levels, except in two when they recovered the IFN-γ production...

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Autor principal:	Costas, Mónica Alejandra
Publicado:	1993
Materias:	Anorexia nervosa DNA synthesis interferon-gamma synthesis gamma interferon interleukin 2 receptor adolescent adult anorexia nervosa article clinical article controlled study dna synthesis female human human cell lymphocyte proliferation monocyte priority journal Adolescent Adult Anorexia Nervosa Cells, Cultured DNA DNA Replication Female Follow-Up Studies Human Interferon Type II Lymphocyte Activation Lymphocytes Monocytes Receptors, Interleukin-2 Support, Non-U.S. Gov't
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02719142_v13_n6_p445_Polack http://hdl.handle.net/20.500.12110/paper_02719142_v13_n6_p445_Polack
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_02719142_v13_n6_p445_Polack
record_format	dspace
spelling	paper:paper_02719142_v13_n6_p445_Polack2023-06-08T15:25:00Z Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients Costas, Mónica Alejandra Anorexia nervosa DNA synthesis interferon-gamma synthesis gamma interferon interleukin 2 receptor adolescent adult anorexia nervosa article clinical article controlled study dna synthesis female human human cell lymphocyte proliferation monocyte priority journal Adolescent Adult Anorexia Nervosa Cells, Cultured DNA DNA Replication Female Follow-Up Studies Human Interferon Type II Lymphocyte Activation Lymphocytes Monocytes Receptors, Interleukin-2 Support, Non-U.S. Gov't Interferon-gamma (IFN-γ) production by peripheral blood mononuclear cells (PBMC) in 14 patients with anorexia nervosa (AN) was significantly lower than in 14 age-matched healthy controls. Follow-up samples in four patients displayed low levels, except in two when they recovered the IFN-γ production as the hormonal cycles were restored. A large interindividual variation for the lymphocyte proliferative response was observed in 30 AN patients. DNA synthesis of PBMC was normal in 8 patients (27%), significantly increased in 6 (20%) (P<0.001), and significantly decreased in 16 (53%) (P<0.001). IFN-γ inhibition was reversed by culturing a control lymphocyte population with monocytes from patients with AN. This was not observed in cultures of control monocytes and AN lymphocytes. IL-2 receptor (TAC subunit) was assessed and no difference was found in the number of TAC-positive cells between patients and controls. These results point out impaired production of the immunomodulator cytokine IFN-γ as a major functional defect of AN peripheral lymphocytes. © 1993 Plenum Publishing Corporation. Fil:Costas, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1993 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02719142_v13_n6_p445_Polack http://hdl.handle.net/20.500.12110/paper_02719142_v13_n6_p445_Polack
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Anorexia nervosa DNA synthesis interferon-gamma synthesis gamma interferon interleukin 2 receptor adolescent adult anorexia nervosa article clinical article controlled study dna synthesis female human human cell lymphocyte proliferation monocyte priority journal Adolescent Adult Anorexia Nervosa Cells, Cultured DNA DNA Replication Female Follow-Up Studies Human Interferon Type II Lymphocyte Activation Lymphocytes Monocytes Receptors, Interleukin-2 Support, Non-U.S. Gov't
spellingShingle	Anorexia nervosa DNA synthesis interferon-gamma synthesis gamma interferon interleukin 2 receptor adolescent adult anorexia nervosa article clinical article controlled study dna synthesis female human human cell lymphocyte proliferation monocyte priority journal Adolescent Adult Anorexia Nervosa Cells, Cultured DNA DNA Replication Female Follow-Up Studies Human Interferon Type II Lymphocyte Activation Lymphocytes Monocytes Receptors, Interleukin-2 Support, Non-U.S. Gov't Costas, Mónica Alejandra Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients
topic_facet	Anorexia nervosa DNA synthesis interferon-gamma synthesis gamma interferon interleukin 2 receptor adolescent adult anorexia nervosa article clinical article controlled study dna synthesis female human human cell lymphocyte proliferation monocyte priority journal Adolescent Adult Anorexia Nervosa Cells, Cultured DNA DNA Replication Female Follow-Up Studies Human Interferon Type II Lymphocyte Activation Lymphocytes Monocytes Receptors, Interleukin-2 Support, Non-U.S. Gov't
description	Interferon-gamma (IFN-γ) production by peripheral blood mononuclear cells (PBMC) in 14 patients with anorexia nervosa (AN) was significantly lower than in 14 age-matched healthy controls. Follow-up samples in four patients displayed low levels, except in two when they recovered the IFN-γ production as the hormonal cycles were restored. A large interindividual variation for the lymphocyte proliferative response was observed in 30 AN patients. DNA synthesis of PBMC was normal in 8 patients (27%), significantly increased in 6 (20%) (P<0.001), and significantly decreased in 16 (53%) (P<0.001). IFN-γ inhibition was reversed by culturing a control lymphocyte population with monocytes from patients with AN. This was not observed in cultures of control monocytes and AN lymphocytes. IL-2 receptor (TAC subunit) was assessed and no difference was found in the number of TAC-positive cells between patients and controls. These results point out impaired production of the immunomodulator cytokine IFN-γ as a major functional defect of AN peripheral lymphocytes. © 1993 Plenum Publishing Corporation.
author	Costas, Mónica Alejandra
author_facet	Costas, Mónica Alejandra
author_sort	Costas, Mónica Alejandra
title	Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients
title_short	Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients
title_full	Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients
title_fullStr	Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients
title_full_unstemmed	Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients
title_sort	low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients
publishDate	1993
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02719142_v13_n6_p445_Polack http://hdl.handle.net/20.500.12110/paper_02719142_v13_n6_p445_Polack
work_keys_str_mv	AT costasmonicaalejandra lowlymphocyteinterferongammaproductionandvariableproliferativeresponseinanorexianervosapatients
_version_	1768542217653190656

Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients

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