Novel effect of serum on the incorporation of [2-3H]mannose into dolichol-bound carbohydrates and proteins

In the present work we report a serum induced decrease in the rate of [2-3H]mannose incorporation into dolichol derivatives and proteins in the embryonic chick optic lobe. This novel effect of serum is widely distributed in sera from different species including man, and it seems to be a unique respo...

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Autores principales: Rossi, Susana Graciela, Carminatti, Héctor
Publicado: 1990
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Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01970186_v16_n3_p295_Rossi
http://hdl.handle.net/20.500.12110/paper_01970186_v16_n3_p295_Rossi
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Sumario:In the present work we report a serum induced decrease in the rate of [2-3H]mannose incorporation into dolichol derivatives and proteins in the embryonic chick optic lobe. This novel effect of serum is widely distributed in sera from different species including man, and it seems to be a unique response of the central nervous system cells. It also appears not to be a generalized toxic effect since it does not affect mannose uptake and deoxyglucose phosphate accumulation. These findings acquire more physiological significance since the in vivo conditions were approached by the preservation of the topological relationship among the cells in each tissue particle and the maintenance of steady state labeling conditions. © 1990.