Inhibition of Junin virus RNA synthesis by an antiviral acridone derivative

There are no specific approved drugs for the treatment of agents of viral hemorrhagic fevers (HF) and antiviral therapies against these viruses are urgently needed. The present study characterizes the potent and selective antiviral activity against the HF causing arenavirus Junin virus (JUNV) of the...

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Detalles Bibliográficos
Autores principales: Sepúlveda, Claudia Soledad, García, Cybele Carina, Fascio, Mirta Liliana, D'Accorso, Norma Beatriz, Damonte, Elsa Beatriz
Publicado: 2012
Materias:
Acridone
Antiviral
Hemorrhagic fever virus
Inosine monophosphate dehydrogenase (IMPDH)
Junin virus
RNA synthesis
10 allyl 6 chloro 4 methoxy 9(10h)acridone
acridone derivative
guanosine
inosinate dehydrogenase
mycophenolic acid
ribavirin
unclassified drug
virus RNA
adsorption
animal cell
antiviral activity
article
controlled study
drug potency
hemorrhagic fever
infection
internalization
nonhuman
priority journal
real time polymerase chain reaction
Vero cell
virogenesis
Acridones
Allyl Compounds
Animals
Antiviral Agents
Cercopithecus aethiops
Cytopathogenic Effect, Viral
Gene Expression Regulation, Viral
Guanosine
Microbial Sensitivity Tests
RNA, Viral
Vero Cells
Virus Replication
Arenavirus
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01663542_v93_n1_p16_Sepulveda
http://hdl.handle.net/20.500.12110/paper_01663542_v93_n1_p16_Sepulveda
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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