Antiviral sulfated steroids from the ophiuroid Ophioplocus januarii
One new and three known sulfated steroidal polyols have been isolated from the ophiuroid Ophioplocus januarii, collected at San Antonio Oeste, Rio Negro, Argentina. The four compounds possess 4α,11β-dihydroxy-3α,21- disulfoxy substituents and the A/B cis ring junction but differ in the side chain. T...
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1996
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v59_n9_p887_Roccatagliata http://hdl.handle.net/20.500.12110/paper_01633864_v59_n9_p887_Roccatagliata |
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paper:paper_01633864_v59_n9_p887_Roccatagliata |
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paper:paper_01633864_v59_n9_p887_Roccatagliata2023-06-08T15:14:10Z Antiviral sulfated steroids from the ophiuroid Ophioplocus januarii 5beta 24 norcholest 22 ene 3alpha,4alpha,11beta,21 tetrol 3,21 disulfate antivirus agent natural product steroid unclassified drug antiviral activity article drug isolation drug structure human human cell invertebrate junin virus nonhuman poliomyelitis virus respiratory syncytial pneumovirus Animals Anti-HIV Agents Cell Survival Cytopathogenic Effect, Viral DNA Replication DNA Viruses RNA Viruses Starfish Sterols Virus Replication Argentina (fish) Invertebrata Junin virus Ophioplocus Ophioplocus januarii Ophiuroidea Polio virus Poliovirus Respiratory syncytial virus RNA viruses One new and three known sulfated steroidal polyols have been isolated from the ophiuroid Ophioplocus januarii, collected at San Antonio Oeste, Rio Negro, Argentina. The four compounds possess 4α,11β-dihydroxy-3α,21- disulfoxy substituents and the A/B cis ring junction but differ in the side chain. The new compound has been characterized as (22E)-5β-24-norcholest- 22-ene-3α,4α,11β,21-tetrol 3,21-disulfate (4). The structures of the four compounds were determined from spectral data and comparison with those of related steroidal polyols. The four compounds were tested for their inhibitory effect on the replication of one DNA and three RNA viruses. Compounds 2 and 4 were active against respiratory syncytial and polio viruses, and compound 3 inhibited Junin virus, responsible for Argentine hemorrhagic fever. 1996 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v59_n9_p887_Roccatagliata http://hdl.handle.net/20.500.12110/paper_01633864_v59_n9_p887_Roccatagliata |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
5beta 24 norcholest 22 ene 3alpha,4alpha,11beta,21 tetrol 3,21 disulfate antivirus agent natural product steroid unclassified drug antiviral activity article drug isolation drug structure human human cell invertebrate junin virus nonhuman poliomyelitis virus respiratory syncytial pneumovirus Animals Anti-HIV Agents Cell Survival Cytopathogenic Effect, Viral DNA Replication DNA Viruses RNA Viruses Starfish Sterols Virus Replication Argentina (fish) Invertebrata Junin virus Ophioplocus Ophioplocus januarii Ophiuroidea Polio virus Poliovirus Respiratory syncytial virus RNA viruses |
| spellingShingle |
5beta 24 norcholest 22 ene 3alpha,4alpha,11beta,21 tetrol 3,21 disulfate antivirus agent natural product steroid unclassified drug antiviral activity article drug isolation drug structure human human cell invertebrate junin virus nonhuman poliomyelitis virus respiratory syncytial pneumovirus Animals Anti-HIV Agents Cell Survival Cytopathogenic Effect, Viral DNA Replication DNA Viruses RNA Viruses Starfish Sterols Virus Replication Argentina (fish) Invertebrata Junin virus Ophioplocus Ophioplocus januarii Ophiuroidea Polio virus Poliovirus Respiratory syncytial virus RNA viruses Antiviral sulfated steroids from the ophiuroid Ophioplocus januarii |
| topic_facet |
5beta 24 norcholest 22 ene 3alpha,4alpha,11beta,21 tetrol 3,21 disulfate antivirus agent natural product steroid unclassified drug antiviral activity article drug isolation drug structure human human cell invertebrate junin virus nonhuman poliomyelitis virus respiratory syncytial pneumovirus Animals Anti-HIV Agents Cell Survival Cytopathogenic Effect, Viral DNA Replication DNA Viruses RNA Viruses Starfish Sterols Virus Replication Argentina (fish) Invertebrata Junin virus Ophioplocus Ophioplocus januarii Ophiuroidea Polio virus Poliovirus Respiratory syncytial virus RNA viruses |
| description |
One new and three known sulfated steroidal polyols have been isolated from the ophiuroid Ophioplocus januarii, collected at San Antonio Oeste, Rio Negro, Argentina. The four compounds possess 4α,11β-dihydroxy-3α,21- disulfoxy substituents and the A/B cis ring junction but differ in the side chain. The new compound has been characterized as (22E)-5β-24-norcholest- 22-ene-3α,4α,11β,21-tetrol 3,21-disulfate (4). The structures of the four compounds were determined from spectral data and comparison with those of related steroidal polyols. The four compounds were tested for their inhibitory effect on the replication of one DNA and three RNA viruses. Compounds 2 and 4 were active against respiratory syncytial and polio viruses, and compound 3 inhibited Junin virus, responsible for Argentine hemorrhagic fever. |
| title |
Antiviral sulfated steroids from the ophiuroid Ophioplocus januarii |
| title_short |
Antiviral sulfated steroids from the ophiuroid Ophioplocus januarii |
| title_full |
Antiviral sulfated steroids from the ophiuroid Ophioplocus januarii |
| title_fullStr |
Antiviral sulfated steroids from the ophiuroid Ophioplocus januarii |
| title_full_unstemmed |
Antiviral sulfated steroids from the ophiuroid Ophioplocus januarii |
| title_sort |
antiviral sulfated steroids from the ophiuroid ophioplocus januarii |
| publishDate |
1996 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v59_n9_p887_Roccatagliata http://hdl.handle.net/20.500.12110/paper_01633864_v59_n9_p887_Roccatagliata |
| _version_ |
1768542263950966784 |