Novel sulfated xylogalactoarabinans from green seaweed Cladophora falklandica: Chemical structure and action on the fibrin network

The water-soluble sulfated xylogalactoarabinans from green seaweed Cladophora falklandica are constituted by a backbone of 4-linked β-L-arabinopyranose units partially sulfated mainly on C3 and also on C2. Besides, partial glycosylation mostly on C2 with single stubs of β-D-xylopyranose, or single s...

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Autores principales: Quintana, Irene Luisa, Ciancia, Marina
Publicado: 2016
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Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v154_n_p139_Arata
http://hdl.handle.net/20.500.12110/paper_01448617_v154_n_p139_Arata
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spelling paper:paper_01448617_v154_n_p139_Arata2023-06-08T15:12:02Z Novel sulfated xylogalactoarabinans from green seaweed Cladophora falklandica: Chemical structure and action on the fibrin network Quintana, Irene Luisa Ciancia, Marina Anticoagulant activity Cladophora Fibrin network Galactofuranose Green seaweed Sulfated arabinan Blood vessels Scanning electron microscopy Anticoagulant activities Arabinans Cladophora Fibrin network Galactofuranose Green seaweed Seaweed anticoagulant agent fibrin polysaccharide sulfate xylopyranose xylose analogs and derivatives animal chemistry conformation drug effects fibrinolysis green alga human Leporidae metabolism preclinical study procedures scanning electron microscopy seaweed Animals Anticoagulants Carbohydrate Conformation Chlorophyta Drug Evaluation, Preclinical Fibrin Fibrinolysis Humans Microscopy, Electron, Scanning Polysaccharides Rabbits Seaweed Sulfates Xylose The water-soluble sulfated xylogalactoarabinans from green seaweed Cladophora falklandica are constituted by a backbone of 4-linked β-L-arabinopyranose units partially sulfated mainly on C3 and also on C2. Besides, partial glycosylation mostly on C2 with single stubs of β-D-xylopyranose, or single stubs of β-D-galactofuranose or short chains comprising (1 → 5)- and/or (1 → 6)-linkages, was also found. These compounds showed anticoagulant activity, although much lower than that of heparin. The effect of a purified fraction (F1) on the fibrin network was studied in detail. It modifies the kinetics of fibrin formation, suggesting an impaired polymerization process. Scanning electron microscopy showed a laxer conformation, with larger interstitial pores than the control. Accordingly, this network was lysed more easily. These fibrin properties would reduce the time of permanence of the clot in the blood vessel, inducing a lesser thrombogenic state. One of the possible mechanisms of its anticoagulant effect is direct thrombin inhibition. © 2016 Elsevier Ltd Fil:Quintana, I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ciancia, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v154_n_p139_Arata http://hdl.handle.net/20.500.12110/paper_01448617_v154_n_p139_Arata
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Anticoagulant activity
Cladophora
Fibrin network
Galactofuranose
Green seaweed
Sulfated arabinan
Blood vessels
Scanning electron microscopy
Anticoagulant activities
Arabinans
Cladophora
Fibrin network
Galactofuranose
Green seaweed
Seaweed
anticoagulant agent
fibrin
polysaccharide
sulfate
xylopyranose
xylose
analogs and derivatives
animal
chemistry
conformation
drug effects
fibrinolysis
green alga
human
Leporidae
metabolism
preclinical study
procedures
scanning electron microscopy
seaweed
Animals
Anticoagulants
Carbohydrate Conformation
Chlorophyta
Drug Evaluation, Preclinical
Fibrin
Fibrinolysis
Humans
Microscopy, Electron, Scanning
Polysaccharides
Rabbits
Seaweed
Sulfates
Xylose
spellingShingle Anticoagulant activity
Cladophora
Fibrin network
Galactofuranose
Green seaweed
Sulfated arabinan
Blood vessels
Scanning electron microscopy
Anticoagulant activities
Arabinans
Cladophora
Fibrin network
Galactofuranose
Green seaweed
Seaweed
anticoagulant agent
fibrin
polysaccharide
sulfate
xylopyranose
xylose
analogs and derivatives
animal
chemistry
conformation
drug effects
fibrinolysis
green alga
human
Leporidae
metabolism
preclinical study
procedures
scanning electron microscopy
seaweed
Animals
Anticoagulants
Carbohydrate Conformation
Chlorophyta
Drug Evaluation, Preclinical
Fibrin
Fibrinolysis
Humans
Microscopy, Electron, Scanning
Polysaccharides
Rabbits
Seaweed
Sulfates
Xylose
Quintana, Irene Luisa
Ciancia, Marina
Novel sulfated xylogalactoarabinans from green seaweed Cladophora falklandica: Chemical structure and action on the fibrin network
topic_facet Anticoagulant activity
Cladophora
Fibrin network
Galactofuranose
Green seaweed
Sulfated arabinan
Blood vessels
Scanning electron microscopy
Anticoagulant activities
Arabinans
Cladophora
Fibrin network
Galactofuranose
Green seaweed
Seaweed
anticoagulant agent
fibrin
polysaccharide
sulfate
xylopyranose
xylose
analogs and derivatives
animal
chemistry
conformation
drug effects
fibrinolysis
green alga
human
Leporidae
metabolism
preclinical study
procedures
scanning electron microscopy
seaweed
Animals
Anticoagulants
Carbohydrate Conformation
Chlorophyta
Drug Evaluation, Preclinical
Fibrin
Fibrinolysis
Humans
Microscopy, Electron, Scanning
Polysaccharides
Rabbits
Seaweed
Sulfates
Xylose
description The water-soluble sulfated xylogalactoarabinans from green seaweed Cladophora falklandica are constituted by a backbone of 4-linked β-L-arabinopyranose units partially sulfated mainly on C3 and also on C2. Besides, partial glycosylation mostly on C2 with single stubs of β-D-xylopyranose, or single stubs of β-D-galactofuranose or short chains comprising (1 → 5)- and/or (1 → 6)-linkages, was also found. These compounds showed anticoagulant activity, although much lower than that of heparin. The effect of a purified fraction (F1) on the fibrin network was studied in detail. It modifies the kinetics of fibrin formation, suggesting an impaired polymerization process. Scanning electron microscopy showed a laxer conformation, with larger interstitial pores than the control. Accordingly, this network was lysed more easily. These fibrin properties would reduce the time of permanence of the clot in the blood vessel, inducing a lesser thrombogenic state. One of the possible mechanisms of its anticoagulant effect is direct thrombin inhibition. © 2016 Elsevier Ltd
author Quintana, Irene Luisa
Ciancia, Marina
author_facet Quintana, Irene Luisa
Ciancia, Marina
author_sort Quintana, Irene Luisa
title Novel sulfated xylogalactoarabinans from green seaweed Cladophora falklandica: Chemical structure and action on the fibrin network
title_short Novel sulfated xylogalactoarabinans from green seaweed Cladophora falklandica: Chemical structure and action on the fibrin network
title_full Novel sulfated xylogalactoarabinans from green seaweed Cladophora falklandica: Chemical structure and action on the fibrin network
title_fullStr Novel sulfated xylogalactoarabinans from green seaweed Cladophora falklandica: Chemical structure and action on the fibrin network
title_full_unstemmed Novel sulfated xylogalactoarabinans from green seaweed Cladophora falklandica: Chemical structure and action on the fibrin network
title_sort novel sulfated xylogalactoarabinans from green seaweed cladophora falklandica: chemical structure and action on the fibrin network
publishDate 2016
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v154_n_p139_Arata
http://hdl.handle.net/20.500.12110/paper_01448617_v154_n_p139_Arata
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