Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

Summary Seasonal changes in disease activity have been observed in multiple sclerosis, an autoimmune disorder that affects the CNS. These epidemiological observations suggest that environmental factors influence the disease course. Here, we report that melatonin levels, whose production is modulated...

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Guardado en:
Detalles Bibliográficos
Publicado: 2015
Materias:
CCAAT enhancer binding protein alpha
interleukin 10
melatonin
mitogen activated protein kinase 1
mitogen activated protein kinase 3
retinoid related orphan receptor alpha
retinoid related orphan receptor gamma
transcription factor
transcription factor Nfil3
unclassified drug
basic leucine zipper transcription factor
CCAAT enhancer binding protein
adult
animal cell
animal experiment
animal model
Article
autumn
cell differentiation
controlled study
disease activity
enzyme activation
experimental allergic encephalitis
female
human
human cell
major clinical study
male
mouse
multiple sclerosis
nonhuman
priority journal
protein expression
regulatory T lymphocyte
seasonal variation
Th17 cell
transactivation
winter
animal
C57BL mouse
cytology
experimental autoimmune encephalomyelitis
immunology
light
metabolism
pathology
recurrent disease
season
signal transduction
Animals
Basic-Leucine Zipper Transcription Factors
CCAAT-Enhancer-Binding Proteins
Cell Differentiation
Encephalomyelitis, Autoimmune, Experimental
Female
Humans
Light
Male
MAP Kinase Signaling System
Melatonin
Mice
Mice, Inbred C57BL
Multiple Sclerosis
Nuclear Receptor Subfamily 1, Group F, Member 3
Recurrence
Seasons
T-Lymphocytes, Regulatory
Th17 Cells
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00928674_v162_n6_p1338_Farez
http://hdl.handle.net/20.500.12110/paper_00928674_v162_n6_p1338_Farez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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