Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells

We explore the dynamic behavior of a model of calcium oscillations and wave propagation in the basal region of pancreatic acinar cells [Sneyd, J., et al., Biophys. J. 85: 1392-1405, 2003]. Since it is known that two principal calcium release pathways are involved, inositol trisphosphate receptors (I...

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Autor principal: Ventura, Alejandra C.
Publicado: 2006
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Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00928240_v68_n8_p2205_Ventura
http://hdl.handle.net/20.500.12110/paper_00928240_v68_n8_p2205_Ventura
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spelling paper:paper_00928240_v68_n8_p2205_Ventura2023-06-08T15:08:23Z Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells Ventura, Alejandra C. Calcium oscillations Calcium waves Pancreatic acinar cells Traveling waves inositol 1,4,5 trisphosphate receptor ryanodine receptor article biological model calcium signaling comparative study human metabolism pancreas physiology Calcium Signaling Humans Inositol 1,4,5-Trisphosphate Receptors Models, Biological Pancreas Ryanodine Receptor Calcium Release Channel We explore the dynamic behavior of a model of calcium oscillations and wave propagation in the basal region of pancreatic acinar cells [Sneyd, J., et al., Biophys. J. 85: 1392-1405, 2003]. Since it is known that two principal calcium release pathways are involved, inositol trisphosphate receptors (IPR) and ryanodine receptors (RyR), we study how the model behavior depends on the density of each receptor type. Calcium oscillations can be mediated either by IPR or RyR. Continuous increases in either RyR or IPR density can lead to the appearance and disappearance of oscillations multiple times, and the two receptor types interact via their common effect on cytoplasmic calcium concentration and the subsequent effect on the total amount of calcium inside the cell. Increases in agonist concentration can stimulate oscillations via the RyR by increasing calcium influx. Using a two time-scale approach, we explain these complex behaviors by treating the total amount of cellular calcium as a slow parameter. Oscillations are controlled by the shape of the slow manifold and where it intersects the nullcline of the slow variable. When calcium diffusion is included, the existence of traveling waves in the model equation is strongly dependent on the interplay between the total amount of calcium in the cell and membrane transport, a feature that can be experimentally tested. Our results help us understand the behavior of a model that includes both receptors in comparison to the properties of each receptor type in isolation. © 2006 Springer Science+Business Media, Inc. Fil:Ventura, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00928240_v68_n8_p2205_Ventura http://hdl.handle.net/20.500.12110/paper_00928240_v68_n8_p2205_Ventura
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Calcium oscillations
Calcium waves
Pancreatic acinar cells
Traveling waves
inositol 1,4,5 trisphosphate receptor
ryanodine receptor
article
biological model
calcium signaling
comparative study
human
metabolism
pancreas
physiology
Calcium Signaling
Humans
Inositol 1,4,5-Trisphosphate Receptors
Models, Biological
Pancreas
Ryanodine Receptor Calcium Release Channel
spellingShingle Calcium oscillations
Calcium waves
Pancreatic acinar cells
Traveling waves
inositol 1,4,5 trisphosphate receptor
ryanodine receptor
article
biological model
calcium signaling
comparative study
human
metabolism
pancreas
physiology
Calcium Signaling
Humans
Inositol 1,4,5-Trisphosphate Receptors
Models, Biological
Pancreas
Ryanodine Receptor Calcium Release Channel
Ventura, Alejandra C.
Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells
topic_facet Calcium oscillations
Calcium waves
Pancreatic acinar cells
Traveling waves
inositol 1,4,5 trisphosphate receptor
ryanodine receptor
article
biological model
calcium signaling
comparative study
human
metabolism
pancreas
physiology
Calcium Signaling
Humans
Inositol 1,4,5-Trisphosphate Receptors
Models, Biological
Pancreas
Ryanodine Receptor Calcium Release Channel
description We explore the dynamic behavior of a model of calcium oscillations and wave propagation in the basal region of pancreatic acinar cells [Sneyd, J., et al., Biophys. J. 85: 1392-1405, 2003]. Since it is known that two principal calcium release pathways are involved, inositol trisphosphate receptors (IPR) and ryanodine receptors (RyR), we study how the model behavior depends on the density of each receptor type. Calcium oscillations can be mediated either by IPR or RyR. Continuous increases in either RyR or IPR density can lead to the appearance and disappearance of oscillations multiple times, and the two receptor types interact via their common effect on cytoplasmic calcium concentration and the subsequent effect on the total amount of calcium inside the cell. Increases in agonist concentration can stimulate oscillations via the RyR by increasing calcium influx. Using a two time-scale approach, we explain these complex behaviors by treating the total amount of cellular calcium as a slow parameter. Oscillations are controlled by the shape of the slow manifold and where it intersects the nullcline of the slow variable. When calcium diffusion is included, the existence of traveling waves in the model equation is strongly dependent on the interplay between the total amount of calcium in the cell and membrane transport, a feature that can be experimentally tested. Our results help us understand the behavior of a model that includes both receptors in comparison to the properties of each receptor type in isolation. © 2006 Springer Science+Business Media, Inc.
author Ventura, Alejandra C.
author_facet Ventura, Alejandra C.
author_sort Ventura, Alejandra C.
title Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells
title_short Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells
title_full Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells
title_fullStr Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells
title_full_unstemmed Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells
title_sort calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells
publishDate 2006
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00928240_v68_n8_p2205_Ventura
http://hdl.handle.net/20.500.12110/paper_00928240_v68_n8_p2205_Ventura
work_keys_str_mv AT venturaalejandrac calciumoscillationsandwavesgeneratedbymultiplereleasemechanismsinpancreaticacinarcells
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