Pathophysiological role of the cytokine network in the anterior pituitary gland

Recent evidence has demonstrated that cytokines and other growth factors act in the anterior pituitary gland. Using the traditional criteria employed to determine autocrine or paracrine functions our review shows that, in addition to their role as lymphocyte messengers, certain cytokines are autocri...

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Autores principales: Páez Pereda, Marcelo, Perez Castro, Carolina Inés
Publicado: 1999
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Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913022_v20_n1_p71_Arzt
http://hdl.handle.net/20.500.12110/paper_00913022_v20_n1_p71_Arzt
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spelling paper:paper_00913022_v20_n1_p71_Arzt2023-06-08T15:08:01Z Pathophysiological role of the cytokine network in the anterior pituitary gland Páez Pereda, Marcelo Perez Castro, Carolina Inés Adenoma growth Anterior pituitary Autocrine/paracrine Cytokines corticotropin interleukin 1 interleukin 1beta interleukin 6 animal cell cell communication cell proliferation cytokine production cytokine release growth regulation human human cell hypophysis adenoma hypophysis function mouse nonhuman pathophysiology priority journal rat review Recent evidence has demonstrated that cytokines and other growth factors act in the anterior pituitary gland. Using the traditional criteria employed to determine autocrine or paracrine functions our review shows that, in addition to their role as lymphocyte messengers, certain cytokines are autocrine or paracrine regulators of anterior pituitary function and growth. The cytokines known to regulate ad/or be expressed in the anterior pituitary include the inflammatory cytokine family (IL-1 and its endogenous antagonist, IL-1ra; TNF-α, and IL-6), the Th1-cytokines (IL-2 and IFN-γ), and other cytokines such as LIF, MIF, and TGF-β. This review examines at the cellular, molecular, and physiological levels whether: (1) each cytokine alters some aspect of pituitary physiology; (2) receptors for the cytokine are expressed in the gland; and (3) the cytokine is produced in the anterior pituitary. Should physiological stimuli regulate pituitary cytokine production, this would constitute additional proof of their autocrine/paracrine role. In this context, we analyze in this review the current literature on the actions of cytokines known to regulate anterior pituitary hormone secretion, selecting the in vivo studies that support the direct action of the cytokine in the anterior pituitary. Further support for direct regulatory action is provided by in vitro studies, in explant cultures or pituitary cell lines. The cytokine receptors that have been demonstrated in the pituitary of several species are also discussed. The endogenous production of the homologous cytokines and the regulation of this expression are analyzed. The evidence indicating that cytokines also regulate the growth and proliferation of pituitary cells is reviewed. This action is particularly important since it suggests that intrinsically produced cytokines may play a role in the pathogenesis of pituitary adenomas. The complex cell to cell communication involved in the action of these factors is discussed. Fil:Pereda, M.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Castro, C.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1999 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913022_v20_n1_p71_Arzt http://hdl.handle.net/20.500.12110/paper_00913022_v20_n1_p71_Arzt
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Adenoma growth
Anterior pituitary
Autocrine/paracrine
Cytokines
corticotropin
interleukin 1
interleukin 1beta
interleukin 6
animal cell
cell communication
cell proliferation
cytokine production
cytokine release
growth regulation
human
human cell
hypophysis adenoma
hypophysis function
mouse
nonhuman
pathophysiology
priority journal
rat
review
spellingShingle Adenoma growth
Anterior pituitary
Autocrine/paracrine
Cytokines
corticotropin
interleukin 1
interleukin 1beta
interleukin 6
animal cell
cell communication
cell proliferation
cytokine production
cytokine release
growth regulation
human
human cell
hypophysis adenoma
hypophysis function
mouse
nonhuman
pathophysiology
priority journal
rat
review
Páez Pereda, Marcelo
Perez Castro, Carolina Inés
Pathophysiological role of the cytokine network in the anterior pituitary gland
topic_facet Adenoma growth
Anterior pituitary
Autocrine/paracrine
Cytokines
corticotropin
interleukin 1
interleukin 1beta
interleukin 6
animal cell
cell communication
cell proliferation
cytokine production
cytokine release
growth regulation
human
human cell
hypophysis adenoma
hypophysis function
mouse
nonhuman
pathophysiology
priority journal
rat
review
description Recent evidence has demonstrated that cytokines and other growth factors act in the anterior pituitary gland. Using the traditional criteria employed to determine autocrine or paracrine functions our review shows that, in addition to their role as lymphocyte messengers, certain cytokines are autocrine or paracrine regulators of anterior pituitary function and growth. The cytokines known to regulate ad/or be expressed in the anterior pituitary include the inflammatory cytokine family (IL-1 and its endogenous antagonist, IL-1ra; TNF-α, and IL-6), the Th1-cytokines (IL-2 and IFN-γ), and other cytokines such as LIF, MIF, and TGF-β. This review examines at the cellular, molecular, and physiological levels whether: (1) each cytokine alters some aspect of pituitary physiology; (2) receptors for the cytokine are expressed in the gland; and (3) the cytokine is produced in the anterior pituitary. Should physiological stimuli regulate pituitary cytokine production, this would constitute additional proof of their autocrine/paracrine role. In this context, we analyze in this review the current literature on the actions of cytokines known to regulate anterior pituitary hormone secretion, selecting the in vivo studies that support the direct action of the cytokine in the anterior pituitary. Further support for direct regulatory action is provided by in vitro studies, in explant cultures or pituitary cell lines. The cytokine receptors that have been demonstrated in the pituitary of several species are also discussed. The endogenous production of the homologous cytokines and the regulation of this expression are analyzed. The evidence indicating that cytokines also regulate the growth and proliferation of pituitary cells is reviewed. This action is particularly important since it suggests that intrinsically produced cytokines may play a role in the pathogenesis of pituitary adenomas. The complex cell to cell communication involved in the action of these factors is discussed.
author Páez Pereda, Marcelo
Perez Castro, Carolina Inés
author_facet Páez Pereda, Marcelo
Perez Castro, Carolina Inés
author_sort Páez Pereda, Marcelo
title Pathophysiological role of the cytokine network in the anterior pituitary gland
title_short Pathophysiological role of the cytokine network in the anterior pituitary gland
title_full Pathophysiological role of the cytokine network in the anterior pituitary gland
title_fullStr Pathophysiological role of the cytokine network in the anterior pituitary gland
title_full_unstemmed Pathophysiological role of the cytokine network in the anterior pituitary gland
title_sort pathophysiological role of the cytokine network in the anterior pituitary gland
publishDate 1999
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913022_v20_n1_p71_Arzt
http://hdl.handle.net/20.500.12110/paper_00913022_v20_n1_p71_Arzt
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