Immunology, signal transduction, and behavior in hypothalamic-pituitary- adrenal axis-related genetic mouse models

A classical view of the neuroendocrine-immune network assumes bidirectional interactions where pro-inflammatory cytokines influence hypothalamic-pituitary- adrenal (HPA) axis-derived hormones that subsequently affect cytokines in a permanently servo-controlled circle. Nevertheless, this picture has...

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Autores principales: Silberstein Cuña, Susana Iris, Bonfiglio, Juan José, Refojo, Damián
Publicado: 2009
Materias:
Behavior
CRF
CRH
ERK
Forced swim test
HPA axis
MAPK
Mouse models
Stress
Stress-coping behavior
β-endorphin
beta endorphin
corticotropin releasing factor
corticotropin releasing factor receptor 1
cytokine
mitogen activated protein kinase
central nervous system
conference paper
coping behavior
cytokine production
gene overexpression
genetic engineering
human
hypothalamus hypophysis adrenal system
immune system
immunocompetent cell
immunomodulation
neuroendocrine system
nonhuman
protein expression
signal transduction
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1153_n_p120_Silberstein
http://hdl.handle.net/20.500.12110/paper_00778923_v1153_n_p120_Silberstein
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00778923_v1153_n_p120_Silberstein
record_format dspace
spelling paper:paper_00778923_v1153_n_p120_Silberstein2023-06-08T15:07:29Z Immunology, signal transduction, and behavior in hypothalamic-pituitary- adrenal axis-related genetic mouse models Silberstein Cuña, Susana Iris Bonfiglio, Juan José Refojo, Damián Behavior CRF CRH ERK Forced swim test HPA axis MAPK Mouse models Stress Stress-coping behavior β-endorphin beta endorphin corticotropin releasing factor corticotropin releasing factor receptor 1 cytokine mitogen activated protein kinase central nervous system conference paper coping behavior cytokine production gene overexpression genetic engineering human hypothalamus hypophysis adrenal system immune system immunocompetent cell immunomodulation neuroendocrine system nonhuman protein expression signal transduction A classical view of the neuroendocrine-immune network assumes bidirectional interactions where pro-inflammatory cytokines influence hypothalamic-pituitary- adrenal (HPA) axis-derived hormones that subsequently affect cytokines in a permanently servo-controlled circle. Nevertheless, this picture has been continuously evolving over the last years as a result of the discovery of redundant expression and extended functions of many of the molecules implicated. Thus, cytokines are not only expressed in cells of the immune system but also in the central nervous system, and many hormones present at hypothalamic- pituitary level are also functionally expressed in the brain as well as in other peripheral organs, including immune cells. Because of this intermingled network of molecules redundantly expressed, the elucidation of the unique roles of HPA axis-related molecules at every level of complexity is one of the major challenges in the field. Genetic engineering in the mouse offers the most convincing method for dissecting in vivo the specific roles of distinct molecules acting in complex networks. Thus, various immunological, behavioral, and signal transduction studies performed with different HPA axis-related mutant mouse lines to delineate the roles of β-endorphin, the type 1 receptor of corticotropin-releasing hormone (CRHR1), and its ligand CRH will be discussed here. © 2009 New York Academy of Sciences. Fil:Silberstein, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bonfiglio, J.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Refojo, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1153_n_p120_Silberstein http://hdl.handle.net/20.500.12110/paper_00778923_v1153_n_p120_Silberstein
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Behavior
CRF
CRH
ERK
Forced swim test
HPA axis
MAPK
Mouse models
Stress
Stress-coping behavior
β-endorphin
beta endorphin
corticotropin releasing factor
corticotropin releasing factor receptor 1
cytokine
mitogen activated protein kinase
central nervous system
conference paper
coping behavior
cytokine production
gene overexpression
genetic engineering
human
hypothalamus hypophysis adrenal system
immune system
immunocompetent cell
immunomodulation
neuroendocrine system
nonhuman
protein expression
signal transduction
spellingShingle Behavior
CRF
CRH
ERK
Forced swim test
HPA axis
MAPK
Mouse models
Stress
Stress-coping behavior
β-endorphin
beta endorphin
corticotropin releasing factor
corticotropin releasing factor receptor 1
cytokine
mitogen activated protein kinase
central nervous system
conference paper
coping behavior
cytokine production
gene overexpression
genetic engineering
human
hypothalamus hypophysis adrenal system
immune system
immunocompetent cell
immunomodulation
neuroendocrine system
nonhuman
protein expression
signal transduction
Silberstein Cuña, Susana Iris
Bonfiglio, Juan José
Refojo, Damián
Immunology, signal transduction, and behavior in hypothalamic-pituitary- adrenal axis-related genetic mouse models
topic_facet Behavior
CRF
CRH
ERK
Forced swim test
HPA axis
MAPK
Mouse models
Stress
Stress-coping behavior
β-endorphin
beta endorphin
corticotropin releasing factor
corticotropin releasing factor receptor 1
cytokine
mitogen activated protein kinase
central nervous system
conference paper
coping behavior
cytokine production
gene overexpression
genetic engineering
human
hypothalamus hypophysis adrenal system
immune system
immunocompetent cell
immunomodulation
neuroendocrine system
nonhuman
protein expression
signal transduction
description A classical view of the neuroendocrine-immune network assumes bidirectional interactions where pro-inflammatory cytokines influence hypothalamic-pituitary- adrenal (HPA) axis-derived hormones that subsequently affect cytokines in a permanently servo-controlled circle. Nevertheless, this picture has been continuously evolving over the last years as a result of the discovery of redundant expression and extended functions of many of the molecules implicated. Thus, cytokines are not only expressed in cells of the immune system but also in the central nervous system, and many hormones present at hypothalamic- pituitary level are also functionally expressed in the brain as well as in other peripheral organs, including immune cells. Because of this intermingled network of molecules redundantly expressed, the elucidation of the unique roles of HPA axis-related molecules at every level of complexity is one of the major challenges in the field. Genetic engineering in the mouse offers the most convincing method for dissecting in vivo the specific roles of distinct molecules acting in complex networks. Thus, various immunological, behavioral, and signal transduction studies performed with different HPA axis-related mutant mouse lines to delineate the roles of β-endorphin, the type 1 receptor of corticotropin-releasing hormone (CRHR1), and its ligand CRH will be discussed here. © 2009 New York Academy of Sciences.
author Silberstein Cuña, Susana Iris
Bonfiglio, Juan José
Refojo, Damián
author_facet Silberstein Cuña, Susana Iris
Bonfiglio, Juan José
Refojo, Damián
author_sort Silberstein Cuña, Susana Iris
title Immunology, signal transduction, and behavior in hypothalamic-pituitary- adrenal axis-related genetic mouse models
title_short Immunology, signal transduction, and behavior in hypothalamic-pituitary- adrenal axis-related genetic mouse models
title_full Immunology, signal transduction, and behavior in hypothalamic-pituitary- adrenal axis-related genetic mouse models
title_fullStr Immunology, signal transduction, and behavior in hypothalamic-pituitary- adrenal axis-related genetic mouse models
title_full_unstemmed Immunology, signal transduction, and behavior in hypothalamic-pituitary- adrenal axis-related genetic mouse models
title_sort immunology, signal transduction, and behavior in hypothalamic-pituitary- adrenal axis-related genetic mouse models
publishDate 2009
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1153_n_p120_Silberstein
http://hdl.handle.net/20.500.12110/paper_00778923_v1153_n_p120_Silberstein
work_keys_str_mv AT silbersteincunasusanairis immunologysignaltransductionandbehaviorinhypothalamicpituitaryadrenalaxisrelatedgeneticmousemodels
AT bonfigliojuanjose immunologysignaltransductionandbehaviorinhypothalamicpituitaryadrenalaxisrelatedgeneticmousemodels
AT refojodamian immunologysignaltransductionandbehaviorinhypothalamicpituitaryadrenalaxisrelatedgeneticmousemodels
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