Synthesis and preliminary biological screening of sterol analogues as new antifungal agents against plant pathogens

In this paperwereport the synthesis of anewfamily of sterol analogues that have two amidic bonds on the side chain. These azasterols were obtained by a straightforward procedure including an Ugi condensation that allows the facile attachment of a polyfunctionalized side chain into the steroidal fram...

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Autores principales:	Cirigliano, Adriana Mónica, Cabrera, Gabriela Myriam, Ramirez, Javier Alberto
Publicado:	2010
Materias:	Antifungal Azasterols Plant pathogens Ugi reaction antifungal agent azasterol derivative diethyl[[n benzyl n[(3beta hydroxypregn 5 ene 20 yl)carbonyl]glycyl]amino]methylphosphonate n [(tert butylcarbamoyl)methyl)n benzyl 3beta hydroxyandrost 5 en 17beta carboxamine n benzyl n[(3beta hydroxypregn 5 ene 20 yl)carbonyl]glycylglycine n[(cyclohexylcarbamoyl)methyl]n benzyl 3beta hydroxypregn 5 ene 20 carboxamide n[(cyclohexylcarbamoyl)methyl]n(2 (1h indol 3 yl)ethyl] 3beta hydroxypregn 5 ene 20 carboxamide n[(cyclohexylcarbamoyl)methyl]n(3,4 dimethoxyphenethyl) 3beta hydroxyandrost 5 en 17beta carboxamide n[(cyclohexylcarbamoyl)methyl]n[3 (4 nitrophenylamino)propyl] 3beta hydroxypregn 5 ene 20 carboxamide n[(tert butylcarbamoyl)methyl]n phenyl 3beta hydroxyandrost 5 en 17beta carboxamide n[(tert butylcarbamoyl)methyl]n(3 hydroxyphenyl)3beta hydroxyandrost 5 en 17beta carboxamide n[(tert-butylcarbamoyl)methyl]n(4 chlorophenyl) 3beta hydroxyandrost 5 en 17beta carboxamide n[(tertbutylcarbamoyl)methyl]n phenyl 3beta hydroxypregn 5 ene 20 carboxamide sterol derivative unclassified drug azasteroid antifungal activity article nonhuman plant disease sterol synthesis chemical structure chemistry drug effects Fusarium microbial sensitivity test nuclear magnetic resonance spectroscopy synthesis Antifungal Agents Azasteroids Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Molecular Structure Fungi
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v75_n10_p659_Alonso http://hdl.handle.net/20.500.12110/paper_0039128X_v75_n10_p659_Alonso
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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