Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase

In order to examine inhibitory effects of hexachlorobenzene metabolites on the hepatic porphyrinogen carboxylyase activity, rat liver cytosol was incubated with uroporphyrinogen III and chlorinated phenols, thiophenols, thioanisoles and benzenes. Then, the occurrence of hepta-, hexa-, penta- and tet...

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Autores principales:	Billi de Catabbi, Silvia Cristina, San Martín de Viale, Leonor Carmen
Publicado:	1986
Materias:	hexachlorobenzene pentachlorophenol tetrachlorohydroquinone uroporphyrinogen decarboxylase animal experiment enzyme inhibition liver metabolite nonhuman pentachlorobenzenethiol priority journal tetrachlorobenzene Animal Carboxy-Lyases Chlorobenzenes Chlorophenols Cytosol Female Hexachlorobenzene Liver Rats Support, Non-U.S. Gov't Uroporphyrinogens
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00345164_v51_n3_p325_Billi http://hdl.handle.net/20.500.12110/paper_00345164_v51_n3_p325_Billi
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00345164_v51_n3_p325_Billi
record_format	dspace
spelling	paper:paper_00345164_v51_n3_p325_Billi2023-06-08T15:00:41Z Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase Billi de Catabbi, Silvia Cristina San Martín de Viale, Leonor Carmen hexachlorobenzene pentachlorophenol tetrachlorohydroquinone uroporphyrinogen decarboxylase animal experiment enzyme inhibition liver metabolite nonhuman pentachlorobenzenethiol priority journal tetrachlorobenzene Animal Carboxy-Lyases Chlorobenzenes Chlorophenols Cytosol Female Hexachlorobenzene Liver Rats Support, Non-U.S. Gov't Uroporphyrinogens In order to examine inhibitory effects of hexachlorobenzene metabolites on the hepatic porphyrinogen carboxylyase activity, rat liver cytosol was incubated with uroporphyrinogen III and chlorinated phenols, thiophenols, thioanisoles and benzenes. Then, the occurrence of hepta-, hexa-, penta- and tetracarboxyporphyrinogen = coproporphyrinogen (measured as porphyrins) was determined. - Inhibitory effects were exerted by tetrachlorohydroquinone, pentachlorophenol, pentachlorothiophenol, 1,2,3,5- and 1,2,4,5- tetrachlorobenzene. Other compounds including hexachlorobenzene which was tested for comparative reasons did not impair uroporphyrinogen decarboxylation. - In the presence of tetrachlorohydroquinone, uroporphyrinogen merely was decarboxylated to hepta- and hexacarboxyporphyrinogen. Under the influence of the other 4 compounds with inhibitory effects, pentacarboxyporphyrinogen and coproporphyrinogen were formed additionally. - Coproporphyrinogen formation was inhibited completely by tetrachlorohydroquinone, while pentachlorophenol diminished its formation by about 50% and pentachlorothiophenol, 1,2,3,5- and 1,2,4,5-tetrachlorobenzene by less than 10%. Fil:Billi, S.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martin de Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1986 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00345164_v51_n3_p325_Billi http://hdl.handle.net/20.500.12110/paper_00345164_v51_n3_p325_Billi
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	hexachlorobenzene pentachlorophenol tetrachlorohydroquinone uroporphyrinogen decarboxylase animal experiment enzyme inhibition liver metabolite nonhuman pentachlorobenzenethiol priority journal tetrachlorobenzene Animal Carboxy-Lyases Chlorobenzenes Chlorophenols Cytosol Female Hexachlorobenzene Liver Rats Support, Non-U.S. Gov't Uroporphyrinogens
spellingShingle	hexachlorobenzene pentachlorophenol tetrachlorohydroquinone uroporphyrinogen decarboxylase animal experiment enzyme inhibition liver metabolite nonhuman pentachlorobenzenethiol priority journal tetrachlorobenzene Animal Carboxy-Lyases Chlorobenzenes Chlorophenols Cytosol Female Hexachlorobenzene Liver Rats Support, Non-U.S. Gov't Uroporphyrinogens Billi de Catabbi, Silvia Cristina San Martín de Viale, Leonor Carmen Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase
topic_facet	hexachlorobenzene pentachlorophenol tetrachlorohydroquinone uroporphyrinogen decarboxylase animal experiment enzyme inhibition liver metabolite nonhuman pentachlorobenzenethiol priority journal tetrachlorobenzene Animal Carboxy-Lyases Chlorobenzenes Chlorophenols Cytosol Female Hexachlorobenzene Liver Rats Support, Non-U.S. Gov't Uroporphyrinogens
description	In order to examine inhibitory effects of hexachlorobenzene metabolites on the hepatic porphyrinogen carboxylyase activity, rat liver cytosol was incubated with uroporphyrinogen III and chlorinated phenols, thiophenols, thioanisoles and benzenes. Then, the occurrence of hepta-, hexa-, penta- and tetracarboxyporphyrinogen = coproporphyrinogen (measured as porphyrins) was determined. - Inhibitory effects were exerted by tetrachlorohydroquinone, pentachlorophenol, pentachlorothiophenol, 1,2,3,5- and 1,2,4,5- tetrachlorobenzene. Other compounds including hexachlorobenzene which was tested for comparative reasons did not impair uroporphyrinogen decarboxylation. - In the presence of tetrachlorohydroquinone, uroporphyrinogen merely was decarboxylated to hepta- and hexacarboxyporphyrinogen. Under the influence of the other 4 compounds with inhibitory effects, pentacarboxyporphyrinogen and coproporphyrinogen were formed additionally. - Coproporphyrinogen formation was inhibited completely by tetrachlorohydroquinone, while pentachlorophenol diminished its formation by about 50% and pentachlorothiophenol, 1,2,3,5- and 1,2,4,5-tetrachlorobenzene by less than 10%.
author	Billi de Catabbi, Silvia Cristina San Martín de Viale, Leonor Carmen
author_facet	Billi de Catabbi, Silvia Cristina San Martín de Viale, Leonor Carmen
author_sort	Billi de Catabbi, Silvia Cristina
title	Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase
title_short	Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase
title_full	Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase
title_fullStr	Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase
title_full_unstemmed	Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase
title_sort	screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase
publishDate	1986
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00345164_v51_n3_p325_Billi http://hdl.handle.net/20.500.12110/paper_00345164_v51_n3_p325_Billi
work_keys_str_mv	AT billidecatabbisilviacristina screeningfortheabilityofhexachlorobenzenemetabolitestodecreaseratliverporphyrinogencarboxylyase AT sanmartindevialeleonorcarmen screeningfortheabilityofhexachlorobenzenemetabolitestodecreaseratliverporphyrinogencarboxylyase
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Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase

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