New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn
Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (12) and four known (36) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated...
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2011
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00320943_v77_n14_p1648_Lang http://hdl.handle.net/20.500.12110/paper_00320943_v77_n14_p1648_Lang |
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paper:paper_00320943_v77_n14_p1648_Lang |
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paper:paper_00320943_v77_n14_p1648_Lang2023-06-08T15:00:07Z New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn Cucurbitaceae cucurbitacins cytotoxicity Wilbrandia ebracteata 2beta,16alpha, tetrahydroxy 10alpha,17alpha cucurbit 5,24 dien 3,11 dione 2beta,16alpha, trihydroxy 10alpha,17alpha cucurbit 5,25 dien 3,11,22 trione cucurbitacin cytotoxic agent unclassified drug Wilbrandia ebracteata extract article chemical structure cucumber cytotoxicity drug isolation human human cell in vitro study mass spectrometry nuclear magnetic resonance plant root Wilbrandia ebracteata Brazil Cell Line, Tumor Cell Survival Chromatography, High Pressure Liquid Cucurbitaceae Cucurbitacins Humans Medicine, Traditional Molecular Structure Plant Extracts Plant Roots Plants, Medicinal Spectrometry, Mass, Electrospray Ionization Cucurbitaceae Wilbrandia ebracteata Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (12) and four known (36) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity. © Georg Thieme Verlag KG Stuttgart·New York·. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00320943_v77_n14_p1648_Lang http://hdl.handle.net/20.500.12110/paper_00320943_v77_n14_p1648_Lang |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cucurbitaceae cucurbitacins cytotoxicity Wilbrandia ebracteata 2beta,16alpha, tetrahydroxy 10alpha,17alpha cucurbit 5,24 dien 3,11 dione 2beta,16alpha, trihydroxy 10alpha,17alpha cucurbit 5,25 dien 3,11,22 trione cucurbitacin cytotoxic agent unclassified drug Wilbrandia ebracteata extract article chemical structure cucumber cytotoxicity drug isolation human human cell in vitro study mass spectrometry nuclear magnetic resonance plant root Wilbrandia ebracteata Brazil Cell Line, Tumor Cell Survival Chromatography, High Pressure Liquid Cucurbitaceae Cucurbitacins Humans Medicine, Traditional Molecular Structure Plant Extracts Plant Roots Plants, Medicinal Spectrometry, Mass, Electrospray Ionization Cucurbitaceae Wilbrandia ebracteata |
| spellingShingle |
Cucurbitaceae cucurbitacins cytotoxicity Wilbrandia ebracteata 2beta,16alpha, tetrahydroxy 10alpha,17alpha cucurbit 5,24 dien 3,11 dione 2beta,16alpha, trihydroxy 10alpha,17alpha cucurbit 5,25 dien 3,11,22 trione cucurbitacin cytotoxic agent unclassified drug Wilbrandia ebracteata extract article chemical structure cucumber cytotoxicity drug isolation human human cell in vitro study mass spectrometry nuclear magnetic resonance plant root Wilbrandia ebracteata Brazil Cell Line, Tumor Cell Survival Chromatography, High Pressure Liquid Cucurbitaceae Cucurbitacins Humans Medicine, Traditional Molecular Structure Plant Extracts Plant Roots Plants, Medicinal Spectrometry, Mass, Electrospray Ionization Cucurbitaceae Wilbrandia ebracteata New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn |
| topic_facet |
Cucurbitaceae cucurbitacins cytotoxicity Wilbrandia ebracteata 2beta,16alpha, tetrahydroxy 10alpha,17alpha cucurbit 5,24 dien 3,11 dione 2beta,16alpha, trihydroxy 10alpha,17alpha cucurbit 5,25 dien 3,11,22 trione cucurbitacin cytotoxic agent unclassified drug Wilbrandia ebracteata extract article chemical structure cucumber cytotoxicity drug isolation human human cell in vitro study mass spectrometry nuclear magnetic resonance plant root Wilbrandia ebracteata Brazil Cell Line, Tumor Cell Survival Chromatography, High Pressure Liquid Cucurbitaceae Cucurbitacins Humans Medicine, Traditional Molecular Structure Plant Extracts Plant Roots Plants, Medicinal Spectrometry, Mass, Electrospray Ionization Cucurbitaceae Wilbrandia ebracteata |
| description |
Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (12) and four known (36) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity. © Georg Thieme Verlag KG Stuttgart·New York·. |
| title |
New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn |
| title_short |
New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn |
| title_full |
New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn |
| title_fullStr |
New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn |
| title_full_unstemmed |
New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn |
| title_sort |
new cytotoxic cucurbitacins from wilbrandia ebracteata cogn |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00320943_v77_n14_p1648_Lang http://hdl.handle.net/20.500.12110/paper_00320943_v77_n14_p1648_Lang |
| _version_ |
1768546337453768704 |