Chemical modifications of algal mannans and xylomannans: Effects on antiviral activity
The structures of two sulfated xylomannans extracted from the red alga Nemalion helminthoides were determined. These two fractions plus a sulfated mannan, isolated from the same alga and whose structure was previously reported, were subjected to chemical modification. The mannan was oversulfated wit...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Publicado: |
2012
|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319422_v73_n_p57_PerezRecalde http://hdl.handle.net/20.500.12110/paper_00319422_v73_n_p57_PerezRecalde |
| Aporte de: |
| id |
paper:paper_00319422_v73_n_p57_PerezRecalde |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_00319422_v73_n_p57_PerezRecalde2023-06-08T14:59:42Z Chemical modifications of algal mannans and xylomannans: Effects on antiviral activity Pérez Recalde, María Mercedes Carlucci, María Josefina Noseda, Miguel D. Matulewicz, María Cristina Anticoagulant activity Antiherpetic activity Nemaliales Nemalion helminthoides Oversulfation of mannans Smith degradation of sulfated xylomannans Sulfated mannans Sulfated xylomannans anticoagulant agent antivirus agent mannan sulfate xylose article chemical structure chemistry Dengue virus drug effect Herpes simplex virus 1 Herpes simplex virus 2 isolation and purification nuclear magnetic resonance red alga Anticoagulants Antiviral Agents Dengue Virus Herpesvirus 1, Human Herpesvirus 2, Human Mannans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Rhodophyta Sulfuric Acid Esters Xylose algae Dengue virus Dengue virus type 2 Human herpesvirus 1 Nemaliales Nemalion helminthoides Rhodophyta The structures of two sulfated xylomannans extracted from the red alga Nemalion helminthoides were determined. These two fractions plus a sulfated mannan, isolated from the same alga and whose structure was previously reported, were subjected to chemical modification. The mannan was oversulfated with SO 3-pyridine in dimethyl sulfoxide at 60 °C during two and three hours and the xylomannans were subjected to Smith degradation in order to eliminate xylose side-chains. Structural analysis of all derivatives was carried out by methylation analysis and 13C NMR spectroscopy. Antiviral activity against herpes simplex virus type 1 and 2, and dengue virus type 2 of native and modified mannans and xylomannans was estimated. Anticoagulant effect of the active fractions was also determined. © 2011 Elsevier Ltd. All rights reserved. Fil:Pérez Recalde, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Carlucci, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Noseda, M.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Matulewicz, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319422_v73_n_p57_PerezRecalde http://hdl.handle.net/20.500.12110/paper_00319422_v73_n_p57_PerezRecalde |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Anticoagulant activity Antiherpetic activity Nemaliales Nemalion helminthoides Oversulfation of mannans Smith degradation of sulfated xylomannans Sulfated mannans Sulfated xylomannans anticoagulant agent antivirus agent mannan sulfate xylose article chemical structure chemistry Dengue virus drug effect Herpes simplex virus 1 Herpes simplex virus 2 isolation and purification nuclear magnetic resonance red alga Anticoagulants Antiviral Agents Dengue Virus Herpesvirus 1, Human Herpesvirus 2, Human Mannans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Rhodophyta Sulfuric Acid Esters Xylose algae Dengue virus Dengue virus type 2 Human herpesvirus 1 Nemaliales Nemalion helminthoides Rhodophyta |
| spellingShingle |
Anticoagulant activity Antiherpetic activity Nemaliales Nemalion helminthoides Oversulfation of mannans Smith degradation of sulfated xylomannans Sulfated mannans Sulfated xylomannans anticoagulant agent antivirus agent mannan sulfate xylose article chemical structure chemistry Dengue virus drug effect Herpes simplex virus 1 Herpes simplex virus 2 isolation and purification nuclear magnetic resonance red alga Anticoagulants Antiviral Agents Dengue Virus Herpesvirus 1, Human Herpesvirus 2, Human Mannans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Rhodophyta Sulfuric Acid Esters Xylose algae Dengue virus Dengue virus type 2 Human herpesvirus 1 Nemaliales Nemalion helminthoides Rhodophyta Pérez Recalde, María Mercedes Carlucci, María Josefina Noseda, Miguel D. Matulewicz, María Cristina Chemical modifications of algal mannans and xylomannans: Effects on antiviral activity |
| topic_facet |
Anticoagulant activity Antiherpetic activity Nemaliales Nemalion helminthoides Oversulfation of mannans Smith degradation of sulfated xylomannans Sulfated mannans Sulfated xylomannans anticoagulant agent antivirus agent mannan sulfate xylose article chemical structure chemistry Dengue virus drug effect Herpes simplex virus 1 Herpes simplex virus 2 isolation and purification nuclear magnetic resonance red alga Anticoagulants Antiviral Agents Dengue Virus Herpesvirus 1, Human Herpesvirus 2, Human Mannans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Rhodophyta Sulfuric Acid Esters Xylose algae Dengue virus Dengue virus type 2 Human herpesvirus 1 Nemaliales Nemalion helminthoides Rhodophyta |
| description |
The structures of two sulfated xylomannans extracted from the red alga Nemalion helminthoides were determined. These two fractions plus a sulfated mannan, isolated from the same alga and whose structure was previously reported, were subjected to chemical modification. The mannan was oversulfated with SO 3-pyridine in dimethyl sulfoxide at 60 °C during two and three hours and the xylomannans were subjected to Smith degradation in order to eliminate xylose side-chains. Structural analysis of all derivatives was carried out by methylation analysis and 13C NMR spectroscopy. Antiviral activity against herpes simplex virus type 1 and 2, and dengue virus type 2 of native and modified mannans and xylomannans was estimated. Anticoagulant effect of the active fractions was also determined. © 2011 Elsevier Ltd. All rights reserved. |
| author |
Pérez Recalde, María Mercedes Carlucci, María Josefina Noseda, Miguel D. Matulewicz, María Cristina |
| author_facet |
Pérez Recalde, María Mercedes Carlucci, María Josefina Noseda, Miguel D. Matulewicz, María Cristina |
| author_sort |
Pérez Recalde, María Mercedes |
| title |
Chemical modifications of algal mannans and xylomannans: Effects on antiviral activity |
| title_short |
Chemical modifications of algal mannans and xylomannans: Effects on antiviral activity |
| title_full |
Chemical modifications of algal mannans and xylomannans: Effects on antiviral activity |
| title_fullStr |
Chemical modifications of algal mannans and xylomannans: Effects on antiviral activity |
| title_full_unstemmed |
Chemical modifications of algal mannans and xylomannans: Effects on antiviral activity |
| title_sort |
chemical modifications of algal mannans and xylomannans: effects on antiviral activity |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319422_v73_n_p57_PerezRecalde http://hdl.handle.net/20.500.12110/paper_00319422_v73_n_p57_PerezRecalde |
| work_keys_str_mv |
AT perezrecaldemariamercedes chemicalmodificationsofalgalmannansandxylomannanseffectsonantiviralactivity AT carluccimariajosefina chemicalmodificationsofalgalmannansandxylomannanseffectsonantiviralactivity AT nosedamigueld chemicalmodificationsofalgalmannansandxylomannanseffectsonantiviralactivity AT matulewiczmariacristina chemicalmodificationsofalgalmannansandxylomannanseffectsonantiviralactivity |
| _version_ |
1768543074470854656 |