The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved

Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as a neuroregulator to integrate the complex neuroendocrine, autonomic, and behavi...

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Autores principales:	Bonfiglio, Juan José, Refojo, Damián, Silberstein Cuña, Susana Iris
Publicado:	2011
Materias:	B-Raf CRH receptor CRH signaling HPA axis MAPK corticotropin releasing factor mitogen activated protein kinase anxiety article depression human hypothalamus hypophysis adrenal system mood disorder nonhuman priority journal signal transduction stress Animals Central Nervous System Corticotropin-Releasing Hormone Humans Hypothalamo-Hypophyseal System Mice Models, Animal Pituitary-Adrenal System Receptors, Corticotropin-Releasing Hormone Signal Transduction
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v94_n1_p12_Bonfiglio http://hdl.handle.net/20.500.12110/paper_00283835_v94_n1_p12_Bonfiglio
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00283835_v94_n1_p12_Bonfiglio
record_format	dspace
spelling	paper:paper_00283835_v94_n1_p12_Bonfiglio2023-06-08T14:55:07Z The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved Bonfiglio, Juan José Refojo, Damián Silberstein Cuña, Susana Iris B-Raf CRH receptor CRH signaling HPA axis MAPK corticotropin releasing factor mitogen activated protein kinase anxiety article depression human hypothalamus hypophysis adrenal system mood disorder nonhuman priority journal signal transduction stress Animals Central Nervous System Corticotropin-Releasing Hormone Humans Hypothalamo-Hypophyseal System Mice Models, Animal Pituitary-Adrenal System Receptors, Corticotropin-Releasing Hormone Signal Transduction Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as a neuroregulator to integrate the complex neuroendocrine, autonomic, and behavioral adaptive response to stress. Hyperactive and/or dysregulated CRH circuits are involved in neuroendocrinological disturbances and stress-related mood disorders such as anxiety and depression. This review describes the main physiological features of the CRH network and summarizes recent relevant information concerning the molecular mechanism of CRH action obtained from signal transduction studies using cells and wild-type and transgenic mice lines. Special focus is placed on the MAPK signaling pathways triggered by CRH through the CRH receptor 1 that plays an essential role in CRH action in pituitary corticotrophs and in specific brain structures. Recent findings underpin the concept of specific CRH-signaling pathways restricted to specific anatomical areas. Understanding CRH action at molecular levels will not only provide insight into the precise CRH mechanism of action, but will also be instrumental in identifying novel targets for pharmacological intervention in neuroendocrine tissues and specific brain areas involved in CRH-related disorders. Copyright © 2011 S. Karger AG, Basel. Fil:Bonfiglio, J.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Refojo, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Silberstein, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v94_n1_p12_Bonfiglio http://hdl.handle.net/20.500.12110/paper_00283835_v94_n1_p12_Bonfiglio
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	B-Raf CRH receptor CRH signaling HPA axis MAPK corticotropin releasing factor mitogen activated protein kinase anxiety article depression human hypothalamus hypophysis adrenal system mood disorder nonhuman priority journal signal transduction stress Animals Central Nervous System Corticotropin-Releasing Hormone Humans Hypothalamo-Hypophyseal System Mice Models, Animal Pituitary-Adrenal System Receptors, Corticotropin-Releasing Hormone Signal Transduction
spellingShingle	B-Raf CRH receptor CRH signaling HPA axis MAPK corticotropin releasing factor mitogen activated protein kinase anxiety article depression human hypothalamus hypophysis adrenal system mood disorder nonhuman priority journal signal transduction stress Animals Central Nervous System Corticotropin-Releasing Hormone Humans Hypothalamo-Hypophyseal System Mice Models, Animal Pituitary-Adrenal System Receptors, Corticotropin-Releasing Hormone Signal Transduction Bonfiglio, Juan José Refojo, Damián Silberstein Cuña, Susana Iris The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved
topic_facet	B-Raf CRH receptor CRH signaling HPA axis MAPK corticotropin releasing factor mitogen activated protein kinase anxiety article depression human hypothalamus hypophysis adrenal system mood disorder nonhuman priority journal signal transduction stress Animals Central Nervous System Corticotropin-Releasing Hormone Humans Hypothalamo-Hypophyseal System Mice Models, Animal Pituitary-Adrenal System Receptors, Corticotropin-Releasing Hormone Signal Transduction
description	Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as a neuroregulator to integrate the complex neuroendocrine, autonomic, and behavioral adaptive response to stress. Hyperactive and/or dysregulated CRH circuits are involved in neuroendocrinological disturbances and stress-related mood disorders such as anxiety and depression. This review describes the main physiological features of the CRH network and summarizes recent relevant information concerning the molecular mechanism of CRH action obtained from signal transduction studies using cells and wild-type and transgenic mice lines. Special focus is placed on the MAPK signaling pathways triggered by CRH through the CRH receptor 1 that plays an essential role in CRH action in pituitary corticotrophs and in specific brain structures. Recent findings underpin the concept of specific CRH-signaling pathways restricted to specific anatomical areas. Understanding CRH action at molecular levels will not only provide insight into the precise CRH mechanism of action, but will also be instrumental in identifying novel targets for pharmacological intervention in neuroendocrine tissues and specific brain areas involved in CRH-related disorders. Copyright © 2011 S. Karger AG, Basel.
author	Bonfiglio, Juan José Refojo, Damián Silberstein Cuña, Susana Iris
author_facet	Bonfiglio, Juan José Refojo, Damián Silberstein Cuña, Susana Iris
author_sort	Bonfiglio, Juan José
title	The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved
title_short	The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved
title_full	The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved
title_fullStr	The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved
title_full_unstemmed	The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved
title_sort	corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: molecular and cellular mechanisms involved
publishDate	2011
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v94_n1_p12_Bonfiglio http://hdl.handle.net/20.500.12110/paper_00283835_v94_n1_p12_Bonfiglio
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The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved

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