Local frustration around enzyme active sites
Conflicting biological goals often meet in the specification of protein sequences for structure and function. Overall, strong energetic conflicts are minimized in folded native states according to the principle of minimal frustration, so that a sequence can spontaneously fold, but local violations o...
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2019
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v116_n10_p4037_Freiberger http://hdl.handle.net/20.500.12110/paper_00278424_v116_n10_p4037_Freiberger |
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