Paraneoplastic neuropathy with positive anti-Hu
The case of a 72-year-old woman presenting sensory neuropathy and anti-Hu antibodies is reported. She was admitted in November 1995 with a one year history of sensory neuropathy. Her first sympoms were painful numbness and dysesthesias in both feet. She experienced progression of the sensory symptom...
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1998
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v58_n2_p197_Parera http://hdl.handle.net/20.500.12110/paper_00257680_v58_n2_p197_Parera |
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paper:paper_00257680_v58_n2_p197_Parera2023-06-08T14:53:31Z Paraneoplastic neuropathy with positive anti-Hu Anti-Hu Neuropathy Sensitive paraneuropathy antinuclear antibody aged article case report computer assisted tomography human immunology lung tumor male paraneoplastic syndrome pathology sensory dysfunction small cell carcinoma Aged Antibodies, Antinuclear Carcinoma, Small Cell Humans Lung Neoplasms Male Paraneoplastic Syndromes Sensation Disorders Tomography, X-Ray Computed The case of a 72-year-old woman presenting sensory neuropathy and anti-Hu antibodies is reported. She was admitted in November 1995 with a one year history of sensory neuropathy. Her first sympoms were painful numbness and dysesthesias in both feet. She experienced progression of the sensory symptoms affecting upper limbs, and clumsiness of gait. One month before admission she complained of diminished strength in both hands. The neurologic examination showed anisocoric fixed pupils, with no reaction to light; convergence miosis was evident in the right eye (Argyll-Robertson pupil). In the lower limbs she had very mild distal weakness, and tendon reflexes were universally abolished. Pin and touch sensation, position sense and pallesthesia were absent in all four limbs. Romberg test was elicited, and a tabetic gait was patent. Pseudoathetotic movements were observed in hands and feet. An ulcer was present in the fifth finger of the right foot. Routine blood biochemistry and hematology showed a ESR of 105 and an increased IgG in the immune-electrophoretic run. Neurophysiologic evaluation disclosed a mild demyelinating neuropathy. Positive anti-Hu antibodies were found in the serum (Western blot - Athena Diagnostics); CSF was normal but not tested for anti-Hu. An abdominal CT scan disclosed multiple hypodense nodules in liver, right adrenal gland and peritoneum. A chest CT scan showed a hyperdense mass in the lower right pulmonary lobe and enlarged retrocava-pretracheal lymph nodes. A biopsy of the peritoneal nodule was performed, showing a metastatic small cell carcinoma. The patient died eight days after discharge. Although multiple organs were affected, she was independent until death, showing an indolent clinical course. 1998 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v58_n2_p197_Parera http://hdl.handle.net/20.500.12110/paper_00257680_v58_n2_p197_Parera |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Anti-Hu Neuropathy Sensitive paraneuropathy antinuclear antibody aged article case report computer assisted tomography human immunology lung tumor male paraneoplastic syndrome pathology sensory dysfunction small cell carcinoma Aged Antibodies, Antinuclear Carcinoma, Small Cell Humans Lung Neoplasms Male Paraneoplastic Syndromes Sensation Disorders Tomography, X-Ray Computed |
spellingShingle |
Anti-Hu Neuropathy Sensitive paraneuropathy antinuclear antibody aged article case report computer assisted tomography human immunology lung tumor male paraneoplastic syndrome pathology sensory dysfunction small cell carcinoma Aged Antibodies, Antinuclear Carcinoma, Small Cell Humans Lung Neoplasms Male Paraneoplastic Syndromes Sensation Disorders Tomography, X-Ray Computed Paraneoplastic neuropathy with positive anti-Hu |
topic_facet |
Anti-Hu Neuropathy Sensitive paraneuropathy antinuclear antibody aged article case report computer assisted tomography human immunology lung tumor male paraneoplastic syndrome pathology sensory dysfunction small cell carcinoma Aged Antibodies, Antinuclear Carcinoma, Small Cell Humans Lung Neoplasms Male Paraneoplastic Syndromes Sensation Disorders Tomography, X-Ray Computed |
description |
The case of a 72-year-old woman presenting sensory neuropathy and anti-Hu antibodies is reported. She was admitted in November 1995 with a one year history of sensory neuropathy. Her first sympoms were painful numbness and dysesthesias in both feet. She experienced progression of the sensory symptoms affecting upper limbs, and clumsiness of gait. One month before admission she complained of diminished strength in both hands. The neurologic examination showed anisocoric fixed pupils, with no reaction to light; convergence miosis was evident in the right eye (Argyll-Robertson pupil). In the lower limbs she had very mild distal weakness, and tendon reflexes were universally abolished. Pin and touch sensation, position sense and pallesthesia were absent in all four limbs. Romberg test was elicited, and a tabetic gait was patent. Pseudoathetotic movements were observed in hands and feet. An ulcer was present in the fifth finger of the right foot. Routine blood biochemistry and hematology showed a ESR of 105 and an increased IgG in the immune-electrophoretic run. Neurophysiologic evaluation disclosed a mild demyelinating neuropathy. Positive anti-Hu antibodies were found in the serum (Western blot - Athena Diagnostics); CSF was normal but not tested for anti-Hu. An abdominal CT scan disclosed multiple hypodense nodules in liver, right adrenal gland and peritoneum. A chest CT scan showed a hyperdense mass in the lower right pulmonary lobe and enlarged retrocava-pretracheal lymph nodes. A biopsy of the peritoneal nodule was performed, showing a metastatic small cell carcinoma. The patient died eight days after discharge. Although multiple organs were affected, she was independent until death, showing an indolent clinical course. |
title |
Paraneoplastic neuropathy with positive anti-Hu |
title_short |
Paraneoplastic neuropathy with positive anti-Hu |
title_full |
Paraneoplastic neuropathy with positive anti-Hu |
title_fullStr |
Paraneoplastic neuropathy with positive anti-Hu |
title_full_unstemmed |
Paraneoplastic neuropathy with positive anti-Hu |
title_sort |
paraneoplastic neuropathy with positive anti-hu |
publishDate |
1998 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v58_n2_p197_Parera http://hdl.handle.net/20.500.12110/paper_00257680_v58_n2_p197_Parera |
_version_ |
1768542975078432768 |