Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol

The biosynthesis of bufadienolides in Bufo paracnemis toads has been studied in different seasons of the year using [2-14C]mevalonic acid, [20-14C]pregnenolone, and [20-14C]cholesterol as precursors. The results showed that the doubly unsaturated δ-lactone ring of the bufadieno-lides is directly der...

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Detalles Bibliográficos
Autores principales: Porto, Ana María, Baralle, Francisco Ernesto, Gros, Eduardo Gervasio
Publicado: 1972
Materias:
bufadienolide derivative
carbon
cholesterol
mevalonic acid
pregnenolone
venom
animal
article
biosynthesis
gallbladder
metabolism
season
toad
Animal
Bufanolides
Bufonidae
Carbon Isotopes
Cholesterol
Gallbladder
Mevalonic Acid
Pregnenolone
Seasons
Venoms
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v3_n1_p11_Porto
http://hdl.handle.net/20.500.12110/paper_00224731_v3_n1_p11_Porto
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The biosynthesis of bufadienolides in Bufo paracnemis toads has been studied in different seasons of the year using [2-14C]mevalonic acid, [20-14C]pregnenolone, and [20-14C]cholesterol as precursors. The results showed that the doubly unsaturated δ-lactone ring of the bufadieno-lides is directly derived from the cholesterol side chain without the compound's prior conversion into pregnenolone. The probable sequence in which the different bufadienolides are formed is discussed. © 1972.

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