Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters

Fifteen illudalane sesquiterpenoids, alcyopterosins A-O (1-15) have been isolated from the subAntarctic soft coral Alcyonium paessleri which was collected at a depth of 200 m near the South Georgia Islands, and their structures were elucidated by spectroscopic techniques. Eight of these compounds (2...

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Detalles Bibliográficos
Autores principales:	Palermo, Jorge Alejandro, Spagnuolo, Carla Cecilia, Seldes, Alicia Marta
Publicado:	2000
Materias:	alcyopterosin A alcyopterosin C alcyopterosin E alcyopterosin H antineoplastic agent illudalane natural product nitric acid derivative sesquiterpenoid unclassified drug antineoplastic activity article cancer cell chemical bond controlled study coral drug cytotoxicity drug isolation drug structure human human cell marine environment nonhuman nuclear Overhauser effect proton nuclear magnetic resonance structure analysis Animals Antarctic Regions Cell Line Cnidaria Esters Humans Magnetic Resonance Spectroscopy Molecular Structure Nitrates Sesquiterpenes Spectroscopy, Fourier Transform Infrared
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223263_v65_n15_p4482_Palermo http://hdl.handle.net/20.500.12110/paper_00223263_v65_n15_p4482_Palermo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00223263_v65_n15_p4482_Palermo
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spelling	paper:paper_00223263_v65_n15_p4482_Palermo2023-06-08T14:49:32Z Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters Palermo, Jorge Alejandro Spagnuolo, Carla Cecilia Seldes, Alicia Marta alcyopterosin A alcyopterosin C alcyopterosin E alcyopterosin H antineoplastic agent illudalane natural product nitric acid derivative sesquiterpenoid unclassified drug antineoplastic activity article cancer cell chemical bond controlled study coral drug cytotoxicity drug isolation drug structure human human cell marine environment nonhuman nuclear Overhauser effect proton nuclear magnetic resonance structure analysis Animals Antarctic Regions Cell Line Cnidaria Esters Humans Magnetic Resonance Spectroscopy Molecular Structure Nitrates Sesquiterpenes Spectroscopy, Fourier Transform Infrared Fifteen illudalane sesquiterpenoids, alcyopterosins A-O (1-15) have been isolated from the subAntarctic soft coral Alcyonium paessleri which was collected at a depth of 200 m near the South Georgia Islands, and their structures were elucidated by spectroscopic techniques. Eight of these compounds (2, 3, 5-8, 10, and 13) are the first natural nitrate esters, while the other four (1, 4, 11, and 12) are chlorinated. These compounds are as well the first illudalane sesquiterpenoids to be isolated from the marine environement. Compounds 1, 3, 5, and 8 showeld mild cytotoxicity toward human tumor cell lines. Fil:Palermo, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Spagnuolo, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Seldes, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2000 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223263_v65_n15_p4482_Palermo http://hdl.handle.net/20.500.12110/paper_00223263_v65_n15_p4482_Palermo
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	alcyopterosin A alcyopterosin C alcyopterosin E alcyopterosin H antineoplastic agent illudalane natural product nitric acid derivative sesquiterpenoid unclassified drug antineoplastic activity article cancer cell chemical bond controlled study coral drug cytotoxicity drug isolation drug structure human human cell marine environment nonhuman nuclear Overhauser effect proton nuclear magnetic resonance structure analysis Animals Antarctic Regions Cell Line Cnidaria Esters Humans Magnetic Resonance Spectroscopy Molecular Structure Nitrates Sesquiterpenes Spectroscopy, Fourier Transform Infrared
spellingShingle	alcyopterosin A alcyopterosin C alcyopterosin E alcyopterosin H antineoplastic agent illudalane natural product nitric acid derivative sesquiterpenoid unclassified drug antineoplastic activity article cancer cell chemical bond controlled study coral drug cytotoxicity drug isolation drug structure human human cell marine environment nonhuman nuclear Overhauser effect proton nuclear magnetic resonance structure analysis Animals Antarctic Regions Cell Line Cnidaria Esters Humans Magnetic Resonance Spectroscopy Molecular Structure Nitrates Sesquiterpenes Spectroscopy, Fourier Transform Infrared Palermo, Jorge Alejandro Spagnuolo, Carla Cecilia Seldes, Alicia Marta Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters
topic_facet	alcyopterosin A alcyopterosin C alcyopterosin E alcyopterosin H antineoplastic agent illudalane natural product nitric acid derivative sesquiterpenoid unclassified drug antineoplastic activity article cancer cell chemical bond controlled study coral drug cytotoxicity drug isolation drug structure human human cell marine environment nonhuman nuclear Overhauser effect proton nuclear magnetic resonance structure analysis Animals Antarctic Regions Cell Line Cnidaria Esters Humans Magnetic Resonance Spectroscopy Molecular Structure Nitrates Sesquiterpenes Spectroscopy, Fourier Transform Infrared
description	Fifteen illudalane sesquiterpenoids, alcyopterosins A-O (1-15) have been isolated from the subAntarctic soft coral Alcyonium paessleri which was collected at a depth of 200 m near the South Georgia Islands, and their structures were elucidated by spectroscopic techniques. Eight of these compounds (2, 3, 5-8, 10, and 13) are the first natural nitrate esters, while the other four (1, 4, 11, and 12) are chlorinated. These compounds are as well the first illudalane sesquiterpenoids to be isolated from the marine environement. Compounds 1, 3, 5, and 8 showeld mild cytotoxicity toward human tumor cell lines.
author	Palermo, Jorge Alejandro Spagnuolo, Carla Cecilia Seldes, Alicia Marta
author_facet	Palermo, Jorge Alejandro Spagnuolo, Carla Cecilia Seldes, Alicia Marta
author_sort	Palermo, Jorge Alejandro
title	Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters
title_short	Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters
title_full	Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters
title_fullStr	Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters
title_full_unstemmed	Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters
title_sort	illudalane sesquiterpenoids from the soft coral alcyonium paessleri: the first natural nitrate esters
publishDate	2000
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223263_v65_n15_p4482_Palermo http://hdl.handle.net/20.500.12110/paper_00223263_v65_n15_p4482_Palermo
work_keys_str_mv	AT palermojorgealejandro illudalanesesquiterpenoidsfromthesoftcoralalcyoniumpaesslerithefirstnaturalnitrateesters AT spagnuolocarlacecilia illudalanesesquiterpenoidsfromthesoftcoralalcyoniumpaesslerithefirstnaturalnitrateesters AT seldesaliciamarta illudalanesesquiterpenoidsfromthesoftcoralalcyoniumpaesslerithefirstnaturalnitrateesters
_version_	1768545496379424768

Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters

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