Proteasome stress leads to APP axonal transport defects by promoting its amyloidogenic processing in lysosomes

Alzheimer disease (AD) pathology includes the accumulation of poly-ubiquitylated (also known as poly-ubiquitinated) proteins and failures in proteasome-dependent degradation. Whereas the distribution of proteasomes and its role in synaptic function have been studied, whether proteasome activity regu...

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Detalles Bibliográficos
Publicado:	2018
Materias:	Alzheimer disease Amyloid precursor protein Axonal transport Lysosome Proteasome amyloid precursor protein proteasome animal cell animal tissue Article cell membrane controlled study fluorescence analysis Golgi complex hippocampus live cell imaging lysosome molecular interaction mouse nerve cell nerve fiber transport newborn nonhuman priority journal protein aggregation protein degradation protein localization protein metabolism protein processing protein transport Western blotting
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219533_v131_n11_p_Otero http://hdl.handle.net/20.500.12110/paper_00219533_v131_n11_p_Otero
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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