Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling

Corticotropin-releasing hormone receptor 1 (CRHR1) activates G protein-dependent and internalization-dependent signaling mechanisms. Here, we report that the cyclic AMP (cAMP) response of CRHR1 in physiologically relevant scenarios engages separate cAMP sources, involving the atypical soluble adenyl...

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Detalles Bibliográficos
Autor principal:	Bonfiglio, Juan José
Publicado:	2016
Materias:	adenylate cyclase corticotropin releasing factor receptor 1 cyclic AMP G protein coupled receptor mitogen activated protein kinase 3 bicarbonate calcium corticotropin releasing factor corticotropin releasing factor receptor cyclic AMP dependent protein kinase guanine nucleotide exchange factor animal cell Article cell interaction controlled study endocytosis enzyme activation enzyme activity nonhuman priority journal protein expression signal transduction 3T3-L1 cell line ACTH secreting cell animal cell membrane drug effects enzymology human metabolism mouse rat solubility 3T3-L1 Cells Adenylyl Cyclases Animals Bicarbonates Calcium Cell Membrane Corticotrophs Corticotropin-Releasing Hormone Cyclic AMP Cyclic AMP-Dependent Protein Kinases Endocytosis Guanine Nucleotide Exchange Factors Humans Mice Rats Receptors, Corticotropin-Releasing Hormone Signal Transduction Solubility
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219525_v214_n2_p181_Inda http://hdl.handle.net/20.500.12110/paper_00219525_v214_n2_p181_Inda
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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