Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation

Mammalian Smaug1/Samd4A is a translational repressor. Here we show that Smaug1 forms mRNA-silencing foci located at postsynapses of hippocampal neurons. These structures, which we have named S-foci, are distinct from P-bodies, stress granules, or other neuronal RNA granules hitherto described, and a...

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Detalles Bibliográficos
Autores principales: Baez, María Verónica, Luchelli, Luciana, Maschi, Darío, Habif, Martín, Thomas, María Gabriela, Boccaccio, Graciela Lidia
Publicado: 2011
Materias:
biological factor
messenger RNA
n methyl dextro aspartic acid
n methyl dextro aspartic acid receptor
smaug1 protein
unclassified drug
article
cell aggregation
cell count
cell membrane depolarization
cell size
controlled study
female
gene silencing
hippocampus
human
human cell
nerve cell plasticity
priority journal
protein expression
RNA binding
RNA translation
synapse
synaptogenesis
Mammalia
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219525_v195_n7_p1141_Baez
http://hdl.handle.net/20.500.12110/paper_00219525_v195_n7_p1141_Baez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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