Association of thoracic aorta calcium and non cardiac vascular events in cardiac disease-free individuals
Objective: Thoracic aorta calcium (TAC) is measurable on the same computed tomography (CT) scan as coronary artery calcium (CAC) but has still unclear clinical value. We assessed TAC and CAC relations with non-cardiac vascular events history in a cohort of subjects at risk for cardiovascular disease...
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2016
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219150_v245_n_p22_Craiem http://hdl.handle.net/20.500.12110/paper_00219150_v245_n_p22_Craiem |
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paper:paper_00219150_v245_n_p22_Craiem2023-06-08T14:43:05Z Association of thoracic aorta calcium and non cardiac vascular events in cardiac disease-free individuals Cardiovascular risk Cerebrovascular disease Coronary artery calcium Peripheral vascular disease Vascular calcification calcium thoracic aorta calcium unclassified drug calcium adult Agatston score aorta arch Article calcification cardiovascular risk computer assisted tomography coronary risk female heart disease human major clinical study male multidetector computed tomography priority journal retrospective study risk Aortic Diseases Argentina calcinosis clinical trial complication coronary angiography coronary artery disease diagnostic imaging follow up France incidence metabolism middle aged multicenter study risk assessment thoracic aorta Aorta, Thoracic Aortic Diseases Argentina Calcinosis Calcium Coronary Angiography Coronary Artery Disease Female Follow-Up Studies France Humans Incidence Male Middle Aged Multidetector Computed Tomography Retrospective Studies Risk Assessment Objective: Thoracic aorta calcium (TAC) is measurable on the same computed tomography (CT) scan as coronary artery calcium (CAC) but has still unclear clinical value. We assessed TAC and CAC relations with non-cardiac vascular events history in a cohort of subjects at risk for cardiovascular disease. Methods: We analyzed retrospectively 1000 consecutive subjects having undergone CAC detection by non-contrast multi-slice CT with measurement field longer than usual in order to measure total TAC including aortic arch calcium. We also determined partial TAC restricted to ascending and descending thoracic aorta sites by removing arch calcium from total TAC. Calcium deposits were measured with a custom made software using Agatston score. Results: Compared with the rest of the cohort, the 30 subjects with non-cardiac vascular event history had higher median values [95% CI] of total TAC (282 [28-1809] vs 39 [0-333], p < 0.01) and partial TAC (4 [0-284] vs 0 [0-5], p < 0.01) but no different value of CAC (73 [0-284] vs 16 [0-148]). Odds ratio [95% CI] of having non-cardiac vascular event per 1-SD increase in log-transformed calcium value was significant for total TAC but not for CAC, if total TAC and CAC were entered separately (1.56 [1.12-2.24], p < 0.01 and 1.13 [0.86-1.50], respectively) or together (1.57 [1.10-2.32], p < 0.01 and 0.98 [0.73-1.32], respectively) in the logistic adjusted model. Conclusion: TAC assessment simultaneous with CAC detection provides complementary information on the extra coronary component of cardiovascular risk beyond CAC's coronary risk prediction. Further studies are required to prospectively confirm this result. © 2015. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219150_v245_n_p22_Craiem http://hdl.handle.net/20.500.12110/paper_00219150_v245_n_p22_Craiem |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cardiovascular risk Cerebrovascular disease Coronary artery calcium Peripheral vascular disease Vascular calcification calcium thoracic aorta calcium unclassified drug calcium adult Agatston score aorta arch Article calcification cardiovascular risk computer assisted tomography coronary risk female heart disease human major clinical study male multidetector computed tomography priority journal retrospective study risk Aortic Diseases Argentina calcinosis clinical trial complication coronary angiography coronary artery disease diagnostic imaging follow up France incidence metabolism middle aged multicenter study risk assessment thoracic aorta Aorta, Thoracic Aortic Diseases Argentina Calcinosis Calcium Coronary Angiography Coronary Artery Disease Female Follow-Up Studies France Humans Incidence Male Middle Aged Multidetector Computed Tomography Retrospective Studies Risk Assessment |
| spellingShingle |
Cardiovascular risk Cerebrovascular disease Coronary artery calcium Peripheral vascular disease Vascular calcification calcium thoracic aorta calcium unclassified drug calcium adult Agatston score aorta arch Article calcification cardiovascular risk computer assisted tomography coronary risk female heart disease human major clinical study male multidetector computed tomography priority journal retrospective study risk Aortic Diseases Argentina calcinosis clinical trial complication coronary angiography coronary artery disease diagnostic imaging follow up France incidence metabolism middle aged multicenter study risk assessment thoracic aorta Aorta, Thoracic Aortic Diseases Argentina Calcinosis Calcium Coronary Angiography Coronary Artery Disease Female Follow-Up Studies France Humans Incidence Male Middle Aged Multidetector Computed Tomography Retrospective Studies Risk Assessment Association of thoracic aorta calcium and non cardiac vascular events in cardiac disease-free individuals |
| topic_facet |
Cardiovascular risk Cerebrovascular disease Coronary artery calcium Peripheral vascular disease Vascular calcification calcium thoracic aorta calcium unclassified drug calcium adult Agatston score aorta arch Article calcification cardiovascular risk computer assisted tomography coronary risk female heart disease human major clinical study male multidetector computed tomography priority journal retrospective study risk Aortic Diseases Argentina calcinosis clinical trial complication coronary angiography coronary artery disease diagnostic imaging follow up France incidence metabolism middle aged multicenter study risk assessment thoracic aorta Aorta, Thoracic Aortic Diseases Argentina Calcinosis Calcium Coronary Angiography Coronary Artery Disease Female Follow-Up Studies France Humans Incidence Male Middle Aged Multidetector Computed Tomography Retrospective Studies Risk Assessment |
| description |
Objective: Thoracic aorta calcium (TAC) is measurable on the same computed tomography (CT) scan as coronary artery calcium (CAC) but has still unclear clinical value. We assessed TAC and CAC relations with non-cardiac vascular events history in a cohort of subjects at risk for cardiovascular disease. Methods: We analyzed retrospectively 1000 consecutive subjects having undergone CAC detection by non-contrast multi-slice CT with measurement field longer than usual in order to measure total TAC including aortic arch calcium. We also determined partial TAC restricted to ascending and descending thoracic aorta sites by removing arch calcium from total TAC. Calcium deposits were measured with a custom made software using Agatston score. Results: Compared with the rest of the cohort, the 30 subjects with non-cardiac vascular event history had higher median values [95% CI] of total TAC (282 [28-1809] vs 39 [0-333], p < 0.01) and partial TAC (4 [0-284] vs 0 [0-5], p < 0.01) but no different value of CAC (73 [0-284] vs 16 [0-148]). Odds ratio [95% CI] of having non-cardiac vascular event per 1-SD increase in log-transformed calcium value was significant for total TAC but not for CAC, if total TAC and CAC were entered separately (1.56 [1.12-2.24], p < 0.01 and 1.13 [0.86-1.50], respectively) or together (1.57 [1.10-2.32], p < 0.01 and 0.98 [0.73-1.32], respectively) in the logistic adjusted model. Conclusion: TAC assessment simultaneous with CAC detection provides complementary information on the extra coronary component of cardiovascular risk beyond CAC's coronary risk prediction. Further studies are required to prospectively confirm this result. © 2015. |
| title |
Association of thoracic aorta calcium and non cardiac vascular events in cardiac disease-free individuals |
| title_short |
Association of thoracic aorta calcium and non cardiac vascular events in cardiac disease-free individuals |
| title_full |
Association of thoracic aorta calcium and non cardiac vascular events in cardiac disease-free individuals |
| title_fullStr |
Association of thoracic aorta calcium and non cardiac vascular events in cardiac disease-free individuals |
| title_full_unstemmed |
Association of thoracic aorta calcium and non cardiac vascular events in cardiac disease-free individuals |
| title_sort |
association of thoracic aorta calcium and non cardiac vascular events in cardiac disease-free individuals |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219150_v245_n_p22_Craiem http://hdl.handle.net/20.500.12110/paper_00219150_v245_n_p22_Craiem |
| _version_ |
1768545358065958912 |