Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens)

1. 1. The kinetic properties of the p-nitrophenylphosphatase (EC 3.1.3.1) from erythrocytes was investigated in DMD-patients and DMD-carriers. 2. 2. A different allosteric behaviour in the p-nitrophenylphosphatase from DMD-patients and DMD-carriers compared to controls is supported by the following...

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Detalles Bibliográficos
Publicado:	1988
Materias:	alkaline phosphatase allosterism case report duchenne muscular dystrophy erythrocyte heterozygote human human cell 4-Nitrophenylphosphatase Alkaline Phosphatase Allosteric Regulation Erythrocyte Membrane Female Fluorides Heterozygote Human In Vitro Kinetics Magnesium Male Muscular Dystrophies Phosphoric Monoester Hydrolases Support, Non-U.S. Gov't
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v20_n7_p703_Goldemberg http://hdl.handle.net/20.500.12110/paper_0020711X_v20_n7_p703_Goldemberg
Aporte de:	Aportado por : Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires .

id	paper:paper_0020711X_v20_n7_p703_Goldemberg
record_format	dspace
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	alkaline phosphatase allosterism case report duchenne muscular dystrophy erythrocyte heterozygote human human cell 4-Nitrophenylphosphatase Alkaline Phosphatase Allosteric Regulation Erythrocyte Membrane Female Fluorides Heterozygote Human In Vitro Kinetics Magnesium Male Muscular Dystrophies Phosphoric Monoester Hydrolases Support, Non-U.S. Gov't
spellingShingle	alkaline phosphatase allosterism case report duchenne muscular dystrophy erythrocyte heterozygote human human cell 4-Nitrophenylphosphatase Alkaline Phosphatase Allosteric Regulation Erythrocyte Membrane Female Fluorides Heterozygote Human In Vitro Kinetics Magnesium Male Muscular Dystrophies Phosphoric Monoester Hydrolases Support, Non-U.S. Gov't Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens)
topic_facet	alkaline phosphatase allosterism case report duchenne muscular dystrophy erythrocyte heterozygote human human cell 4-Nitrophenylphosphatase Alkaline Phosphatase Allosteric Regulation Erythrocyte Membrane Female Fluorides Heterozygote Human In Vitro Kinetics Magnesium Male Muscular Dystrophies Phosphoric Monoester Hydrolases Support, Non-U.S. Gov't
description	1. 1. The kinetic properties of the p-nitrophenylphosphatase (EC 3.1.3.1) from erythrocytes was investigated in DMD-patients and DMD-carriers. 2. 2. A different allosteric behaviour in the p-nitrophenylphosphatase from DMD-patients and DMD-carriers compared to controls is supported by the following finclings: (a) values of n altered in F- inhibition of (K+-activated p-nitrophenylphosphatase with Hill coefficients -1.5, -2.2 and -3.1; (b) heterotropic effect of increased concentration of Mg2+ on F- inhibition which is reverted by K+ in DMD-carriers and in control, but not in DMD-patients. 3. 3. Evidence is presented showing that in DMD-patients and in DMD-carriers the interaction membrane-enzyme is different from the corresponcling controls. © 1988.
title	Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens)
title_short	Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens)
title_full	Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens)
title_fullStr	Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens)
title_full_unstemmed	Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens)
title_sort	allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (dmd) patients and duchenne muscular dystrophy carriers (homo sapiens)
publishDate	1988
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v20_n7_p703_Goldemberg http://hdl.handle.net/20.500.12110/paper_0020711X_v20_n7_p703_Goldemberg
bdutipo_str	Repositorios
_version_	1764820559036678144

Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens)

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