Effect of cadmium on porphyrin biosynthesis-I
1. 1. Female Sprague-Dawley rats were exposed to Cd (50 ppm) administered in drinking water. 2. 2. The oral uptake of Cd did not alter δ-aminolevulinate and porphobilinogen urinary excretion nor the total content of daily porphyrin excretion in either urine or feces. 3. 3. A significant and consiste...
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| Autores principales: | , |
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| Publicado: |
1980
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v12_n5-6_p905_EvaKesten http://hdl.handle.net/20.500.12110/paper_0020711X_v12_n5-6_p905_EvaKesten |
| Aporte de: |
| Sumario: | 1. 1. Female Sprague-Dawley rats were exposed to Cd (50 ppm) administered in drinking water. 2. 2. The oral uptake of Cd did not alter δ-aminolevulinate and porphobilinogen urinary excretion nor the total content of daily porphyrin excretion in either urine or feces. 3. 3. A significant and consistent difference in the composition of porphyrin in feces between control and Cd-exposed rats was observed. In the latter group a constant increase of coproporphyrin and a concomitant decrease in protoporphyrin was found. 4. 4. After 94 days exposure, Cd levels in blood and urine were low, and very high in kidney and liver. In red cells the activity of ALA-D was 40% reduced, and only a 20% decrease was observed for PBGase and deaminase. In kidney and liver ALA-D, PBGase and deaminase activities were the same in both control and Cd-intoxicated rats. 5. 5. It is suggested that determination of the ratio protoporphyrin:coproporphyrin in feces and ALA-D activity in red cells might be a biological index of Cd intoxication. © 1980. |
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