Trypanosoma cruzi trans-sialidase prevents elicitation of Th1 cell response via interleukin 10 and downregulates Th1 effector cells

The trans-sialidases (TSs) from Trypanosoma cruzi, the agent of Chagas disease, are virulence factors shed to the bloodstream that induce strong alterations in the immune system. Here, we report that both enzymatically active TS (aTS) and its lectinlike isoform (iTS) disturb CD4 T cell physiology, i...

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Detalles Bibliográficos
Autores principales: Musikant, Alejandro Daniel, Leguizamón, María Susana, Campetella, Oscar Eduardo
Publicado: 2015
Materias:
gamma interferon
interleukin 10
interleukin 2
interleukin 4
neutralizing antibody
ovalbumin
protein kinase ZAP 70
sialidase
T lymphocyte receptor
trans sialidase
unclassified drug
glycoprotein
immunologic factor
trans-sialidase
virulence factor
animal cell
animal experiment
antigen presenting cell
Article
CD4+ T lymphocyte
cell expansion
cell interaction
cell stimulation
cell survival
clone
controlled study
cytokine production
cytokine release
down regulation
effector cell
enzyme activity
in vivo study
male
mouse
nonhuman
parasite survival
phenotype
polarization
priority journal
protein expression
Th1 cell
Trypanosoma cruzi
upregulation
animal
Bagg albino mouse
immune evasion
immunology
metabolism
secretion (process)
Animals
Glycoproteins
Immune Evasion
Immunologic Factors
Interferon-gamma
Interleukin-10
Interleukin-2
Interleukin-4
Male
Mice, Inbred BALB C
Neuraminidase
Th1 Cells
Virulence Factors
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00199567_v83_n5_p2099_Diaz
http://hdl.handle.net/20.500.12110/paper_00199567_v83_n5_p2099_Diaz
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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