Chromatin, DNA structure and alternative splicing
Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin...
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paper:paper_00145793_v589_n22_p3370_NietoMoreno2023-06-08T14:37:44Z Chromatin, DNA structure and alternative splicing Giono, Luciana Eugenia Muñoz, Manuel Javier Kornblihtt, Alberto Rodolfo Alternative splicing Chromatin structure Non-B DNA RNA polymerase II elongation binding protein cystic fibrosis transmembrane conductance regulator DNA interacting protein fibronectin hemoglobin alpha chain messenger RNA protein bcl x protein SRSF3 RNA polymerase II serine arginine rich protein transcription factor unclassified drug chromatin DNA alpha globin gene alternative RNA splicing base pairing Bcl x gene CFTR gene chromatin structure CpG island DNA conformation DNA methylation DNA modification DNA sequence DNA structure DNA template DNA transcription enzyme phosphorylation exon fibronectin gene gene expression genetic association histone modification human intron kinetics nonhuman nucleosome priority journal protein processing Review RNA processing transcription elongation transcription regulation animal chemistry chromatin genetic transcription genetics Alternative Splicing Animals Chromatin DNA Humans Transcription, Genetic Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin compaction. These may affect alternative splicing decisions by inducing pauses or decreasing elongation rate that change the time-window for splicing regulatory sequences to be recognized. Herein we discuss the evidence supporting the influence of template structural modifications on transcription and splicing, and provide insights about possible roles of non-B DNA conformations on the regulation of alternative splicing. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Fil:Giono, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Muñoz, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v589_n22_p3370_NietoMoreno http://hdl.handle.net/20.500.12110/paper_00145793_v589_n22_p3370_NietoMoreno |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Alternative splicing Chromatin structure Non-B DNA RNA polymerase II elongation binding protein cystic fibrosis transmembrane conductance regulator DNA interacting protein fibronectin hemoglobin alpha chain messenger RNA protein bcl x protein SRSF3 RNA polymerase II serine arginine rich protein transcription factor unclassified drug chromatin DNA alpha globin gene alternative RNA splicing base pairing Bcl x gene CFTR gene chromatin structure CpG island DNA conformation DNA methylation DNA modification DNA sequence DNA structure DNA template DNA transcription enzyme phosphorylation exon fibronectin gene gene expression genetic association histone modification human intron kinetics nonhuman nucleosome priority journal protein processing Review RNA processing transcription elongation transcription regulation animal chemistry chromatin genetic transcription genetics Alternative Splicing Animals Chromatin DNA Humans Transcription, Genetic |
spellingShingle |
Alternative splicing Chromatin structure Non-B DNA RNA polymerase II elongation binding protein cystic fibrosis transmembrane conductance regulator DNA interacting protein fibronectin hemoglobin alpha chain messenger RNA protein bcl x protein SRSF3 RNA polymerase II serine arginine rich protein transcription factor unclassified drug chromatin DNA alpha globin gene alternative RNA splicing base pairing Bcl x gene CFTR gene chromatin structure CpG island DNA conformation DNA methylation DNA modification DNA sequence DNA structure DNA template DNA transcription enzyme phosphorylation exon fibronectin gene gene expression genetic association histone modification human intron kinetics nonhuman nucleosome priority journal protein processing Review RNA processing transcription elongation transcription regulation animal chemistry chromatin genetic transcription genetics Alternative Splicing Animals Chromatin DNA Humans Transcription, Genetic Giono, Luciana Eugenia Muñoz, Manuel Javier Kornblihtt, Alberto Rodolfo Chromatin, DNA structure and alternative splicing |
topic_facet |
Alternative splicing Chromatin structure Non-B DNA RNA polymerase II elongation binding protein cystic fibrosis transmembrane conductance regulator DNA interacting protein fibronectin hemoglobin alpha chain messenger RNA protein bcl x protein SRSF3 RNA polymerase II serine arginine rich protein transcription factor unclassified drug chromatin DNA alpha globin gene alternative RNA splicing base pairing Bcl x gene CFTR gene chromatin structure CpG island DNA conformation DNA methylation DNA modification DNA sequence DNA structure DNA template DNA transcription enzyme phosphorylation exon fibronectin gene gene expression genetic association histone modification human intron kinetics nonhuman nucleosome priority journal protein processing Review RNA processing transcription elongation transcription regulation animal chemistry chromatin genetic transcription genetics Alternative Splicing Animals Chromatin DNA Humans Transcription, Genetic |
description |
Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin compaction. These may affect alternative splicing decisions by inducing pauses or decreasing elongation rate that change the time-window for splicing regulatory sequences to be recognized. Herein we discuss the evidence supporting the influence of template structural modifications on transcription and splicing, and provide insights about possible roles of non-B DNA conformations on the regulation of alternative splicing. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
author |
Giono, Luciana Eugenia Muñoz, Manuel Javier Kornblihtt, Alberto Rodolfo |
author_facet |
Giono, Luciana Eugenia Muñoz, Manuel Javier Kornblihtt, Alberto Rodolfo |
author_sort |
Giono, Luciana Eugenia |
title |
Chromatin, DNA structure and alternative splicing |
title_short |
Chromatin, DNA structure and alternative splicing |
title_full |
Chromatin, DNA structure and alternative splicing |
title_fullStr |
Chromatin, DNA structure and alternative splicing |
title_full_unstemmed |
Chromatin, DNA structure and alternative splicing |
title_sort |
chromatin, dna structure and alternative splicing |
publishDate |
2015 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v589_n22_p3370_NietoMoreno http://hdl.handle.net/20.500.12110/paper_00145793_v589_n22_p3370_NietoMoreno |
work_keys_str_mv |
AT gionolucianaeugenia chromatindnastructureandalternativesplicing AT munozmanueljavier chromatindnastructureandalternativesplicing AT kornblihttalbertorodolfo chromatindnastructureandalternativesplicing |
_version_ |
1768546659196731392 |