Chromatin, DNA structure and alternative splicing

Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin...

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Autores principales: Giono, Luciana Eugenia, Muñoz, Manuel Javier, Kornblihtt, Alberto Rodolfo
Publicado: 2015
Materias:
DNA
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v589_n22_p3370_NietoMoreno
http://hdl.handle.net/20.500.12110/paper_00145793_v589_n22_p3370_NietoMoreno
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spelling paper:paper_00145793_v589_n22_p3370_NietoMoreno2023-06-08T14:37:44Z Chromatin, DNA structure and alternative splicing Giono, Luciana Eugenia Muñoz, Manuel Javier Kornblihtt, Alberto Rodolfo Alternative splicing Chromatin structure Non-B DNA RNA polymerase II elongation binding protein cystic fibrosis transmembrane conductance regulator DNA interacting protein fibronectin hemoglobin alpha chain messenger RNA protein bcl x protein SRSF3 RNA polymerase II serine arginine rich protein transcription factor unclassified drug chromatin DNA alpha globin gene alternative RNA splicing base pairing Bcl x gene CFTR gene chromatin structure CpG island DNA conformation DNA methylation DNA modification DNA sequence DNA structure DNA template DNA transcription enzyme phosphorylation exon fibronectin gene gene expression genetic association histone modification human intron kinetics nonhuman nucleosome priority journal protein processing Review RNA processing transcription elongation transcription regulation animal chemistry chromatin genetic transcription genetics Alternative Splicing Animals Chromatin DNA Humans Transcription, Genetic Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin compaction. These may affect alternative splicing decisions by inducing pauses or decreasing elongation rate that change the time-window for splicing regulatory sequences to be recognized. Herein we discuss the evidence supporting the influence of template structural modifications on transcription and splicing, and provide insights about possible roles of non-B DNA conformations on the regulation of alternative splicing. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Fil:Giono, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Muñoz, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v589_n22_p3370_NietoMoreno http://hdl.handle.net/20.500.12110/paper_00145793_v589_n22_p3370_NietoMoreno
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Alternative splicing
Chromatin structure
Non-B DNA
RNA polymerase II elongation
binding protein
cystic fibrosis transmembrane conductance regulator
DNA interacting protein
fibronectin
hemoglobin alpha chain
messenger RNA
protein bcl x
protein SRSF3
RNA polymerase II
serine arginine rich protein
transcription factor
unclassified drug
chromatin
DNA
alpha globin gene
alternative RNA splicing
base pairing
Bcl x gene
CFTR gene
chromatin structure
CpG island
DNA conformation
DNA methylation
DNA modification
DNA sequence
DNA structure
DNA template
DNA transcription
enzyme phosphorylation
exon
fibronectin gene
gene expression
genetic association
histone modification
human
intron
kinetics
nonhuman
nucleosome
priority journal
protein processing
Review
RNA processing
transcription elongation
transcription regulation
animal
chemistry
chromatin
genetic transcription
genetics
Alternative Splicing
Animals
Chromatin
DNA
Humans
Transcription, Genetic
spellingShingle Alternative splicing
Chromatin structure
Non-B DNA
RNA polymerase II elongation
binding protein
cystic fibrosis transmembrane conductance regulator
DNA interacting protein
fibronectin
hemoglobin alpha chain
messenger RNA
protein bcl x
protein SRSF3
RNA polymerase II
serine arginine rich protein
transcription factor
unclassified drug
chromatin
DNA
alpha globin gene
alternative RNA splicing
base pairing
Bcl x gene
CFTR gene
chromatin structure
CpG island
DNA conformation
DNA methylation
DNA modification
DNA sequence
DNA structure
DNA template
DNA transcription
enzyme phosphorylation
exon
fibronectin gene
gene expression
genetic association
histone modification
human
intron
kinetics
nonhuman
nucleosome
priority journal
protein processing
Review
RNA processing
transcription elongation
transcription regulation
animal
chemistry
chromatin
genetic transcription
genetics
Alternative Splicing
Animals
Chromatin
DNA
Humans
Transcription, Genetic
Giono, Luciana Eugenia
Muñoz, Manuel Javier
Kornblihtt, Alberto Rodolfo
Chromatin, DNA structure and alternative splicing
topic_facet Alternative splicing
Chromatin structure
Non-B DNA
RNA polymerase II elongation
binding protein
cystic fibrosis transmembrane conductance regulator
DNA interacting protein
fibronectin
hemoglobin alpha chain
messenger RNA
protein bcl x
protein SRSF3
RNA polymerase II
serine arginine rich protein
transcription factor
unclassified drug
chromatin
DNA
alpha globin gene
alternative RNA splicing
base pairing
Bcl x gene
CFTR gene
chromatin structure
CpG island
DNA conformation
DNA methylation
DNA modification
DNA sequence
DNA structure
DNA template
DNA transcription
enzyme phosphorylation
exon
fibronectin gene
gene expression
genetic association
histone modification
human
intron
kinetics
nonhuman
nucleosome
priority journal
protein processing
Review
RNA processing
transcription elongation
transcription regulation
animal
chemistry
chromatin
genetic transcription
genetics
Alternative Splicing
Animals
Chromatin
DNA
Humans
Transcription, Genetic
description Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin compaction. These may affect alternative splicing decisions by inducing pauses or decreasing elongation rate that change the time-window for splicing regulatory sequences to be recognized. Herein we discuss the evidence supporting the influence of template structural modifications on transcription and splicing, and provide insights about possible roles of non-B DNA conformations on the regulation of alternative splicing. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
author Giono, Luciana Eugenia
Muñoz, Manuel Javier
Kornblihtt, Alberto Rodolfo
author_facet Giono, Luciana Eugenia
Muñoz, Manuel Javier
Kornblihtt, Alberto Rodolfo
author_sort Giono, Luciana Eugenia
title Chromatin, DNA structure and alternative splicing
title_short Chromatin, DNA structure and alternative splicing
title_full Chromatin, DNA structure and alternative splicing
title_fullStr Chromatin, DNA structure and alternative splicing
title_full_unstemmed Chromatin, DNA structure and alternative splicing
title_sort chromatin, dna structure and alternative splicing
publishDate 2015
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v589_n22_p3370_NietoMoreno
http://hdl.handle.net/20.500.12110/paper_00145793_v589_n22_p3370_NietoMoreno
work_keys_str_mv AT gionolucianaeugenia chromatindnastructureandalternativesplicing
AT munozmanueljavier chromatindnastructureandalternativesplicing
AT kornblihttalbertorodolfo chromatindnastructureandalternativesplicing
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