Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J

IIB-MEL-J is a highly heterogeneous newly established human melanoma cell line. The addition of 3 mM, l-tyrosine to the culture medium produced (1) a great decrease in the cell growth rate, (2) a loss of the anchorage-independent growth capacity, and (3) a change in the morphology of the cells to a...

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Detalles Bibliográficos
Autores principales:	Guerra, Liliana Noemí, Bover, Laura del Carmen
Publicado:	1990
Materias:	melanin tyrosine article cell culture cell differentiation human human cell melanoma cell priority journal Cell Adhesion Cell Separation Cell Transformation, Neoplastic Centrifugation, Density Gradient Human Lung Neoplasms Melanins Melanoma Middle Age Support, Non-U.S. Gov't Tumor Cells, Cultured Tyrosine
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144827_v188_n1_p61_Guerra http://hdl.handle.net/20.500.12110/paper_00144827_v188_n1_p61_Guerra
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00144827_v188_n1_p61_Guerra
record_format	dspace
spelling	paper:paper_00144827_v188_n1_p61_Guerra2023-06-08T14:37:15Z Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J Guerra, Liliana Noemí Bover, Laura del Carmen melanin tyrosine article cell culture cell differentiation human human cell melanoma cell priority journal Cell Adhesion Cell Separation Cell Transformation, Neoplastic Centrifugation, Density Gradient Human Lung Neoplasms Melanins Melanoma Middle Age Support, Non-U.S. Gov't Tumor Cells, Cultured Tyrosine IIB-MEL-J is a highly heterogeneous newly established human melanoma cell line. The addition of 3 mM, l-tyrosine to the culture medium produced (1) a great decrease in the cell growth rate, (2) a loss of the anchorage-independent growth capacity, and (3) a change in the morphology of the cells to a fibroblastoid aspect. Coincident with these changes, an increase in subpopulations I and II and a decrease in subpopulations III and IV took place. In view of this evidence we consider that the cells have differentiated. The melanin production was not increased by the l-tyrosine treatment, suggesting that differentiation and melanin expression are not strictly correlated. © 1990. Fil:Guerra, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bover, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1990 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144827_v188_n1_p61_Guerra http://hdl.handle.net/20.500.12110/paper_00144827_v188_n1_p61_Guerra
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	melanin tyrosine article cell culture cell differentiation human human cell melanoma cell priority journal Cell Adhesion Cell Separation Cell Transformation, Neoplastic Centrifugation, Density Gradient Human Lung Neoplasms Melanins Melanoma Middle Age Support, Non-U.S. Gov't Tumor Cells, Cultured Tyrosine
spellingShingle	melanin tyrosine article cell culture cell differentiation human human cell melanoma cell priority journal Cell Adhesion Cell Separation Cell Transformation, Neoplastic Centrifugation, Density Gradient Human Lung Neoplasms Melanins Melanoma Middle Age Support, Non-U.S. Gov't Tumor Cells, Cultured Tyrosine Guerra, Liliana Noemí Bover, Laura del Carmen Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J
topic_facet	melanin tyrosine article cell culture cell differentiation human human cell melanoma cell priority journal Cell Adhesion Cell Separation Cell Transformation, Neoplastic Centrifugation, Density Gradient Human Lung Neoplasms Melanins Melanoma Middle Age Support, Non-U.S. Gov't Tumor Cells, Cultured Tyrosine
description	IIB-MEL-J is a highly heterogeneous newly established human melanoma cell line. The addition of 3 mM, l-tyrosine to the culture medium produced (1) a great decrease in the cell growth rate, (2) a loss of the anchorage-independent growth capacity, and (3) a change in the morphology of the cells to a fibroblastoid aspect. Coincident with these changes, an increase in subpopulations I and II and a decrease in subpopulations III and IV took place. In view of this evidence we consider that the cells have differentiated. The melanin production was not increased by the l-tyrosine treatment, suggesting that differentiation and melanin expression are not strictly correlated. © 1990.
author	Guerra, Liliana Noemí Bover, Laura del Carmen
author_facet	Guerra, Liliana Noemí Bover, Laura del Carmen
author_sort	Guerra, Liliana Noemí
title	Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J
title_short	Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J
title_full	Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J
title_fullStr	Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J
title_full_unstemmed	Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J
title_sort	differentiating effect of l-tyrosine on the human melanoma cell line iib-mel-j
publishDate	1990
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00144827_v188_n1_p61_Guerra http://hdl.handle.net/20.500.12110/paper_00144827_v188_n1_p61_Guerra
work_keys_str_mv	AT guerraliliananoemi differentiatingeffectofltyrosineonthehumanmelanomacelllineiibmelj AT boverlauradelcarmen differentiatingeffectofltyrosineonthehumanmelanomacelllineiibmelj
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Differentiating effect of l-tyrosine on the human melanoma cell line IIB-MEL-J

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