Effect of sugar-phosphate mixtures on the stability of DPPC membranes in dehydrated systems
The stabilizing role of sugars on dehydrated membranes is well established. The formation of a glassy matrix and the direct interaction between the sugars and the lipids are some of the mechanisms proposed to be involved in this stabilizing effect. Phospholipidic systems have been studied extensivel...
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00112240_v48_n1_p81_Ohtake http://hdl.handle.net/20.500.12110/paper_00112240_v48_n1_p81_Ohtake |
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paper:paper_00112240_v48_n1_p81_Ohtake2023-06-08T14:34:49Z Effect of sugar-phosphate mixtures on the stability of DPPC membranes in dehydrated systems Schebor, Carolina C. Glass transition Glasses Lipids Sucrose Trehalose Vacuum-drying biomaterial carbohydrate choline derivative dipalmitoylphosphatidylcholine phosphate phospholipid derivative stabilizing agent sugar article artificial membrane chemical analysis complex formation glass transition temperature melting point molecular interaction physical chemistry priority journal The stabilizing role of sugars on dehydrated membranes is well established. The formation of a glassy matrix and the direct interaction between the sugars and the lipids are some of the mechanisms proposed to be involved in this stabilizing effect. Phospholipidic systems have been studied extensively as models for biological membranes and also due to the practical applications of liposomes as vehicles for drug delivery. In this work, we evaluate the effect of sugar-phosphate mixtures on the transition temperature of dehydrated 1,2-dipalmitoylphosphatidylcholine, and also examine some physical characteristics of these mixtures, such as the glass transition temperature and water sorption properties. The addition of phosphate salts to sugar systems has several interesting features that merit its consideration in formulations to protect dehydrated labile biomaterials. In particular, sucrose-phosphate mixtures provide an interesting alternative to pure saccharide formulations due to their high glass transition temperatures and their increased ability to maintain a low melting transition temperature in the presence of small amounts of water. © 2004 Published by Elsevier Inc. Fil:Schebor, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2004 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00112240_v48_n1_p81_Ohtake http://hdl.handle.net/20.500.12110/paper_00112240_v48_n1_p81_Ohtake |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Glass transition Glasses Lipids Sucrose Trehalose Vacuum-drying biomaterial carbohydrate choline derivative dipalmitoylphosphatidylcholine phosphate phospholipid derivative stabilizing agent sugar article artificial membrane chemical analysis complex formation glass transition temperature melting point molecular interaction physical chemistry priority journal |
| spellingShingle |
Glass transition Glasses Lipids Sucrose Trehalose Vacuum-drying biomaterial carbohydrate choline derivative dipalmitoylphosphatidylcholine phosphate phospholipid derivative stabilizing agent sugar article artificial membrane chemical analysis complex formation glass transition temperature melting point molecular interaction physical chemistry priority journal Schebor, Carolina C. Effect of sugar-phosphate mixtures on the stability of DPPC membranes in dehydrated systems |
| topic_facet |
Glass transition Glasses Lipids Sucrose Trehalose Vacuum-drying biomaterial carbohydrate choline derivative dipalmitoylphosphatidylcholine phosphate phospholipid derivative stabilizing agent sugar article artificial membrane chemical analysis complex formation glass transition temperature melting point molecular interaction physical chemistry priority journal |
| description |
The stabilizing role of sugars on dehydrated membranes is well established. The formation of a glassy matrix and the direct interaction between the sugars and the lipids are some of the mechanisms proposed to be involved in this stabilizing effect. Phospholipidic systems have been studied extensively as models for biological membranes and also due to the practical applications of liposomes as vehicles for drug delivery. In this work, we evaluate the effect of sugar-phosphate mixtures on the transition temperature of dehydrated 1,2-dipalmitoylphosphatidylcholine, and also examine some physical characteristics of these mixtures, such as the glass transition temperature and water sorption properties. The addition of phosphate salts to sugar systems has several interesting features that merit its consideration in formulations to protect dehydrated labile biomaterials. In particular, sucrose-phosphate mixtures provide an interesting alternative to pure saccharide formulations due to their high glass transition temperatures and their increased ability to maintain a low melting transition temperature in the presence of small amounts of water. © 2004 Published by Elsevier Inc. |
| author |
Schebor, Carolina C. |
| author_facet |
Schebor, Carolina C. |
| author_sort |
Schebor, Carolina C. |
| title |
Effect of sugar-phosphate mixtures on the stability of DPPC membranes in dehydrated systems |
| title_short |
Effect of sugar-phosphate mixtures on the stability of DPPC membranes in dehydrated systems |
| title_full |
Effect of sugar-phosphate mixtures on the stability of DPPC membranes in dehydrated systems |
| title_fullStr |
Effect of sugar-phosphate mixtures on the stability of DPPC membranes in dehydrated systems |
| title_full_unstemmed |
Effect of sugar-phosphate mixtures on the stability of DPPC membranes in dehydrated systems |
| title_sort |
effect of sugar-phosphate mixtures on the stability of dppc membranes in dehydrated systems |
| publishDate |
2004 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00112240_v48_n1_p81_Ohtake http://hdl.handle.net/20.500.12110/paper_00112240_v48_n1_p81_Ohtake |
| work_keys_str_mv |
AT scheborcarolinac effectofsugarphosphatemixturesonthestabilityofdppcmembranesindehydratedsystems |
| _version_ |
1768545355183423488 |