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spelling paper:paper_00099120_v35_n1_p65_Romero2023-06-08T14:34:09Z Tamm-Horsfall protein excretion to predict the onset of renal insufficiency Nesse, Alcira Beatriz Biochemical markers Immunotherapy Liver transplantation Nephrotoxicity Renal insufficiency Tamm-Horsfall Protein creatinine Tamm Horsfall glycoprotein adult aged article clinical article controlled study creatinine blood level disease marker enzyme linked immunosorbent assay female human kidney failure liver transplantation male prediction priority journal protein secretion protein synthesis urinalysis urinary excretion Adolescent Adult Aged Biological Markers Creatinine Female Humans Immunoassay Kidney Kidney Failure Kidney Transplantation Male Middle Aged Mucoproteins Time Factors Objective: Immunosuppressive therapy after liver transplantation may be a risk for kidney dysfunction. This work was designed to determine whether Tamm-Horsfall Protein (THP) could be considered as a marker for nephrotoxicity. Design and Methods: THP was determined by an ELISA method in serial 24-h urine from liver transplant patients. Fourteen patients suffered renal insufficiency (LTr1) and 20 showed no acute renal damage (LTr2) after liver transplantation. Results: No clear association could be seen between daily THP excretion and plasma creatinine levels by comparing serial samples collected at the same time. Nevertheless, significant differences were observed in pretransplant THP excretion between both groups of patients. The results (Median/Interquartile Range) were: Controls: 113.2/84.9 to 146.8 mg/24 h (n = 30); LTr1: 36.9/18.3 to 54.5 mg/24 h (p≪0.001 with respect to C and LTr2); LTr2: 90.8/61.5 to 139.7 mg/24 h. Conclusions: The higher pretransplant synthesis and/or secretion of THP seem to have a protective role on the kidney during and after liver transplantation. © 2002 The Canadian Society of Clinical Chemists. All rights reserved. Fil:Nesse, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2002 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099120_v35_n1_p65_Romero http://hdl.handle.net/20.500.12110/paper_00099120_v35_n1_p65_Romero
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Biochemical markers
Immunotherapy
Liver transplantation
Nephrotoxicity
Renal insufficiency
Tamm-Horsfall Protein
creatinine
Tamm Horsfall glycoprotein
adult
aged
article
clinical article
controlled study
creatinine blood level
disease marker
enzyme linked immunosorbent assay
female
human
kidney failure
liver transplantation
male
prediction
priority journal
protein secretion
protein synthesis
urinalysis
urinary excretion
Adolescent
Adult
Aged
Biological Markers
Creatinine
Female
Humans
Immunoassay
Kidney
Kidney Failure
Kidney Transplantation
Male
Middle Aged
Mucoproteins
Time Factors
spellingShingle Biochemical markers
Immunotherapy
Liver transplantation
Nephrotoxicity
Renal insufficiency
Tamm-Horsfall Protein
creatinine
Tamm Horsfall glycoprotein
adult
aged
article
clinical article
controlled study
creatinine blood level
disease marker
enzyme linked immunosorbent assay
female
human
kidney failure
liver transplantation
male
prediction
priority journal
protein secretion
protein synthesis
urinalysis
urinary excretion
Adolescent
Adult
Aged
Biological Markers
Creatinine
Female
Humans
Immunoassay
Kidney
Kidney Failure
Kidney Transplantation
Male
Middle Aged
Mucoproteins
Time Factors
Nesse, Alcira Beatriz
Tamm-Horsfall protein excretion to predict the onset of renal insufficiency
topic_facet Biochemical markers
Immunotherapy
Liver transplantation
Nephrotoxicity
Renal insufficiency
Tamm-Horsfall Protein
creatinine
Tamm Horsfall glycoprotein
adult
aged
article
clinical article
controlled study
creatinine blood level
disease marker
enzyme linked immunosorbent assay
female
human
kidney failure
liver transplantation
male
prediction
priority journal
protein secretion
protein synthesis
urinalysis
urinary excretion
Adolescent
Adult
Aged
Biological Markers
Creatinine
Female
Humans
Immunoassay
Kidney
Kidney Failure
Kidney Transplantation
Male
Middle Aged
Mucoproteins
Time Factors
description Objective: Immunosuppressive therapy after liver transplantation may be a risk for kidney dysfunction. This work was designed to determine whether Tamm-Horsfall Protein (THP) could be considered as a marker for nephrotoxicity. Design and Methods: THP was determined by an ELISA method in serial 24-h urine from liver transplant patients. Fourteen patients suffered renal insufficiency (LTr1) and 20 showed no acute renal damage (LTr2) after liver transplantation. Results: No clear association could be seen between daily THP excretion and plasma creatinine levels by comparing serial samples collected at the same time. Nevertheless, significant differences were observed in pretransplant THP excretion between both groups of patients. The results (Median/Interquartile Range) were: Controls: 113.2/84.9 to 146.8 mg/24 h (n = 30); LTr1: 36.9/18.3 to 54.5 mg/24 h (p≪0.001 with respect to C and LTr2); LTr2: 90.8/61.5 to 139.7 mg/24 h. Conclusions: The higher pretransplant synthesis and/or secretion of THP seem to have a protective role on the kidney during and after liver transplantation. © 2002 The Canadian Society of Clinical Chemists. All rights reserved.
author Nesse, Alcira Beatriz
author_facet Nesse, Alcira Beatriz
author_sort Nesse, Alcira Beatriz
title Tamm-Horsfall protein excretion to predict the onset of renal insufficiency
title_short Tamm-Horsfall protein excretion to predict the onset of renal insufficiency
title_full Tamm-Horsfall protein excretion to predict the onset of renal insufficiency
title_fullStr Tamm-Horsfall protein excretion to predict the onset of renal insufficiency
title_full_unstemmed Tamm-Horsfall protein excretion to predict the onset of renal insufficiency
title_sort tamm-horsfall protein excretion to predict the onset of renal insufficiency
publishDate 2002
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099120_v35_n1_p65_Romero
http://hdl.handle.net/20.500.12110/paper_00099120_v35_n1_p65_Romero
work_keys_str_mv AT nessealcirabeatriz tammhorsfallproteinexcretiontopredicttheonsetofrenalinsufficiency
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