Homocysteine, vitamin B 12 and folate in Alzheimer's and vascular dementias: The paradoxical effect of the superimposed type II diabetes mellitus condition

Background: Increased concentration of plasmatic homocysteine (tHcy) and decreased vitamin B 12 (B12) and folate (FOL) are associated with Alzheimer's (AD) and vascular (VaD) dementias, with type II diabetes mellitus (DM), and reported as risk factors of these diseases. Methods: The sample (n =...

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Detalles Bibliográficos
Autor principal: Marschoff, Enrique R.
Publicado: 2005
Materias:
Dementia of the Alzheimer's type
Dementia risk factors
Folate
Homocysteine
Non-insulin-dependent type II diabetes mellitus
Vascular dementia
Vitamin B 12
cyanocobalamin
folic acid
homocysteine
aged
Alzheimer disease
article
blood level
blood sampling
controlled study
female
human
male
multiinfarct dementia
non insulin dependent diabetes mellitus
priority journal
risk factor
sample size
statistical analysis
Aged
Alzheimer Disease
Analysis of Variance
Dementia, Vascular
Diabetes Mellitus, Type 2
Female
Folic Acid
Humans
Male
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00098981_v359_n1-2_p163_Dominguez
http://hdl.handle.net/20.500.12110/paper_00098981_v359_n1-2_p163_Dominguez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Background: Increased concentration of plasmatic homocysteine (tHcy) and decreased vitamin B 12 (B12) and folate (FOL) are associated with Alzheimer's (AD) and vascular (VaD) dementias, with type II diabetes mellitus (DM), and reported as risk factors of these diseases. Methods: The sample (n = 122; males = 60; mean age = 73 ± 7 years) comprised AD and VaD patients without DM, with a concomitant DM (AD + DM, VaD + DM), DM alone and controls (CTR), resulting in 6 groups. tHcy, B12 and FOL were determined in duplicate. Results: The one-way ANOVA yielded significant differences between groups for all variables: tHcy p < 10-12; B12 p < 10-3; FOL p < 10-4. Significance for comparisons between groups was set at α = 0.05, using the Bonferroni's statistic. The comparisons: DM vs. CTR, AD + DM vs. AD, VaD + DM vs. VaD, and DM demented vs. DM non-demented resulted significant for all variables, except for B12 in 2 comparisons. Conclusions: In demented and control subjects, tHcy and FOL exhibit extreme differences, not so marked between DM and controls. Demented patients with concomitant diabetes are closer to controls than their non-diabetic counterparts. Diabetes affects tHcy and FOL values, which are changed with opposite sign to non-demented. These results suggests a paradoxical phenomenon when diabetes is superimposed to dementias. © 2005 Elsevier B.V. All rights reserved.

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