Synthesis of β-D-galactofuranosyl nucleoside analogues. A new type of β-D-galactofuranosidase inhibitor

The development of β-D-galactofuranosidase inhibitors provides a good chemotherapeutic target for treatment of major human diseases, because β-D-galactofuranose is a constituent of important pathogen microorganisms but is absent in mammals. With this purpose we have prepared β-D-galactofuranosyl nuc...

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Detalles Bibliográficos
Autores principales:	Marino, María Carla, Muchnik de Lederkremer, Rosa María
Publicado:	2001
Materias:	4-Imidazoline Galactofuranosidase inhibitors Imidazolidine-2-thion derivatives Isothiocyanate Thiohydantoin Bioassay Chemotherapy Enzyme inhibition Microorganisms Synthesis (chemical) Nucleophiles Carbohydrates 1,3 diaza 1 beta dextro galactofuranosyl 2 thione beta dextro galactofuranosidase beta dextro galactofuranosidase inhibitor beta dextro galactofuranosyl isothiocyanate carbohydrate derivative dextro galactono 1,4 lactone enzyme inhibitor fungal enzyme imidazolidine derivative imidazoline derivative isothiocyanic acid derivative ketone derivative n beta dextro galactofuranosyl 4 imidazoline 2 thione n beta dextro galactofuranosyl 4 methoxyimidazoline 2 thione n beta dextro galactofuranosyl 4 oxoimidazolidine 2 thione n beta dextro galactofuranosyl o ethylthiourethane unclassified drug article chemical reaction drug screening drug structure drug synthesis enzyme activity enzyme inhibition priority journal structure activity relation beta-Galactosidase Galactosides Humans Molecular Structure Nucleosides Penicillium Thioglycosides Mammalia
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v333_n2_p123_Marino http://hdl.handle.net/20.500.12110/paper_00086215_v333_n2_p123_Marino
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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