Chemical modification of glycosaminoglycans. Selective 2-sulfation of D-glucuronic acid units in heparan sulfate

O-Sulfation of heparan sulfate was performed in conditions that minimise N-desulfation. NMR spectra and methylation analysis of sulfated heparan sulfate confirmed the selective substitution at O-2 of glucuronic acid units.

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Detalles Bibliográficos
Autores principales:	Kovensky, José Eduardo, Fernández Cirelli, Alicia
Publicado:	1997
Materias:	D-Glucuronic acid Heparan sulfate Sulfation glycosaminoglycan heparan sulfate article chemical modification methylation nuclear magnetic resonance spectroscopy priority journal reaction analysis sulfation
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v303_n1_p119_Kovensky http://hdl.handle.net/20.500.12110/paper_00086215_v303_n1_p119_Kovensky
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Descripción
Sumario:	O-Sulfation of heparan sulfate was performed in conditions that minimise N-desulfation. NMR spectra and methylation analysis of sulfated heparan sulfate confirmed the selective substitution at O-2 of glucuronic acid units.