Diabetes alters the reactivity of myocardium to a thromboxane analogue
Atrial contractile response to U-46619 was studied in auricles from normal and acutely diabetic rats. U-46619 induced an increment of dF/dt in diabetic atria, whereas nondiabetic auricles elicited a negative contractile effect. Blockers of arachidonic acid metabolism via cyclooxygenase inhibited the...
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1987
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00084212_v65_n4_p499_Canga http://hdl.handle.net/20.500.12110/paper_00084212_v65_n4_p499_Canga |
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paper:paper_00084212_v65_n4_p499_Canga2023-06-08T14:32:01Z Diabetes alters the reactivity of myocardium to a thromboxane analogue 1 acetyl 2 (8 chloro 10,11 dihydrodibenz[b,f][1,4]oxazepine 10 carbonyl)hydrazine 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid dithizone imidazole indometacin lipoxygenase nictindole nordihydroguaiaretic acid prostaglandin synthase thromboxane derivative tranylcypromine animal animal cell diabetes mellitus dose response drug administration drug antagonism drug efficacy drug interaction drug mechanism endocrine system etiology heart heart muscle heart muscle contractility in vitro study pharmacokinetics priority journal rat Atrial contractile response to U-46619 was studied in auricles from normal and acutely diabetic rats. U-46619 induced an increment of dF/dt in diabetic atria, whereas nondiabetic auricles elicited a negative contractile effect. Blockers of arachidonic acid metabolism via cyclooxygenase inhibited the stimulatory action of U-46619 in diabetic preparations. Moreover, inhibitors of thromboxane synthesis completely blocked the stimulatory effects of U-46619. The stimulant action of the thromboxane A2 mimetic was attenuated when diabetic auricles were incubated with lipoxygenase(s) blocking agents. Results suggest that in diabetic atria the abnormal inotropic effect induced by U-46619 may be associated with thromboxane formation and with lipoxygenase(s) metabolites. 1987 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00084212_v65_n4_p499_Canga http://hdl.handle.net/20.500.12110/paper_00084212_v65_n4_p499_Canga |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
1 acetyl 2 (8 chloro 10,11 dihydrodibenz[b,f][1,4]oxazepine 10 carbonyl)hydrazine 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid dithizone imidazole indometacin lipoxygenase nictindole nordihydroguaiaretic acid prostaglandin synthase thromboxane derivative tranylcypromine animal animal cell diabetes mellitus dose response drug administration drug antagonism drug efficacy drug interaction drug mechanism endocrine system etiology heart heart muscle heart muscle contractility in vitro study pharmacokinetics priority journal rat |
| spellingShingle |
1 acetyl 2 (8 chloro 10,11 dihydrodibenz[b,f][1,4]oxazepine 10 carbonyl)hydrazine 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid dithizone imidazole indometacin lipoxygenase nictindole nordihydroguaiaretic acid prostaglandin synthase thromboxane derivative tranylcypromine animal animal cell diabetes mellitus dose response drug administration drug antagonism drug efficacy drug interaction drug mechanism endocrine system etiology heart heart muscle heart muscle contractility in vitro study pharmacokinetics priority journal rat Diabetes alters the reactivity of myocardium to a thromboxane analogue |
| topic_facet |
1 acetyl 2 (8 chloro 10,11 dihydrodibenz[b,f][1,4]oxazepine 10 carbonyl)hydrazine 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid acetylsalicylic acid dithizone imidazole indometacin lipoxygenase nictindole nordihydroguaiaretic acid prostaglandin synthase thromboxane derivative tranylcypromine animal animal cell diabetes mellitus dose response drug administration drug antagonism drug efficacy drug interaction drug mechanism endocrine system etiology heart heart muscle heart muscle contractility in vitro study pharmacokinetics priority journal rat |
| description |
Atrial contractile response to U-46619 was studied in auricles from normal and acutely diabetic rats. U-46619 induced an increment of dF/dt in diabetic atria, whereas nondiabetic auricles elicited a negative contractile effect. Blockers of arachidonic acid metabolism via cyclooxygenase inhibited the stimulatory action of U-46619 in diabetic preparations. Moreover, inhibitors of thromboxane synthesis completely blocked the stimulatory effects of U-46619. The stimulant action of the thromboxane A2 mimetic was attenuated when diabetic auricles were incubated with lipoxygenase(s) blocking agents. Results suggest that in diabetic atria the abnormal inotropic effect induced by U-46619 may be associated with thromboxane formation and with lipoxygenase(s) metabolites. |
| title |
Diabetes alters the reactivity of myocardium to a thromboxane analogue |
| title_short |
Diabetes alters the reactivity of myocardium to a thromboxane analogue |
| title_full |
Diabetes alters the reactivity of myocardium to a thromboxane analogue |
| title_fullStr |
Diabetes alters the reactivity of myocardium to a thromboxane analogue |
| title_full_unstemmed |
Diabetes alters the reactivity of myocardium to a thromboxane analogue |
| title_sort |
diabetes alters the reactivity of myocardium to a thromboxane analogue |
| publishDate |
1987 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00084212_v65_n4_p499_Canga http://hdl.handle.net/20.500.12110/paper_00084212_v65_n4_p499_Canga |
| _version_ |
1768545627646459904 |