P38γ activation triggers dynamical changes in allosteric docking sites

Mitogen-activated protein kinases (MAPKs) are serine-threonine kinases that participate in signal transduction pathways. p38 MAPKs have four isoforms (p38β, p38β, p38γ, and p38δ) which are involved in multiple cellular functions such as proliferation, differentiation, survival, and migration. MAPK k...

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Detalles Bibliográficos
Autores principales:	Rodriguez Limardo, Ramiro Gonzalo, Ferreiro, Dardo N., Martí, Marcelo Adrián, Turjanski, Adrián Gustavo
Publicado:	2011
Materias:	Activation loops Active site ATP binding Bound state Catalytic activity Conformational change Correlated dynamics Docking sites Dynamical fluctuations Isoforms Key factors MD simulation Mitogen activated protein kinase Molecular dynamics techniques Multiple cellular functions Protein domains Protein dynamics Protein-protein interactions Signal transduction pathways Signaling networks Threonine kinase Two domains Amino acids Binding energy Docking Dynamics Enzymes Molecular dynamics Phosphorylation Plasticity Signal transduction Signaling Catalyst activity adenosine triphosphate mitogen activated protein kinase p38 mitogen activated protein kinase p38 gamma unclassified drug article binding site conformational transition enzyme activation enzyme active site enzyme conformation enzyme phosphorylation molecular dynamics motion priority journal protein domain protein protein interaction simulation Adenosine Triphosphate Allosteric Regulation Enzyme Activation Mitogen-Activated Protein Kinase 12 Molecular Dynamics Simulation Movement Protein Structure, Secondary Protein Structure, Tertiary
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062960_v50_n8_p1384_RodriguezLimardo http://hdl.handle.net/20.500.12110/paper_00062960_v50_n8_p1384_RodriguezLimardo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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