Insulin Activates Glycerol-3-phosphate Acyltransferase (de Novo Phosphatidic Acid Synthesis) through a Phospholipid-Derived Mediator. Apparent Involvement of Giα and Activation of a Phospholipase C

We studied the mechanism whereby insulin activates de novo phosphatidic acid synthesis in BC3H-1 myocytes. Insulin rapidly activated glycerol-3-phosphate acyltransferase (G3PAT) in intact and cell-free preparations of myocytes in a dose-related manner. The apparent Km of the enzyme was decreased by...

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Detalles Bibliográficos
Publicado:	1990
Materias:	1-phosphatidylinositol phosphodiesterase Bordetella virulence factor fluoride sodium glycerol 3 phosphate acyltransferase Glycerol 3 Phosphate O Acyltransferase GTP Binding Proteins guanine nucleotide binding protein inositol phosphate inositol phosphate glycan insulin phosphatidic acid phosphatidylinositol phosphodiesterase phosphodiesterase polysaccharide diacylglycerol phospholipase c animal article biosynthesis cell culture chemistry cytosol drug effect enzyme activation kinetics metabolism mouse muscle signal transduction muscle cell nonhuman priority journal Animal Cells, Cultured Cytosol Enzyme Activation Glycerol-3-Phosphate O-Acyltransferase GTP-Binding Proteins Inositol Phosphates Insulin Kinetics Mice Muscles Phosphatidic Acids Phosphoric Diester Hydrolases Polysaccharides Signal Transduction Sodium Fluoride Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Virulence Factors, Bordetella
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062960_v29_n37_p8735_delVila http://hdl.handle.net/20.500.12110/paper_00062960_v29_n37_p8735_delVila
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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