Intrinsic Feedbacks in MAPK Signaling Cascades Lead to Bistability and Oscillations

Previous studies have demonstrated that double phosphorylation of a protein can lead to bistability if some conditions are fulfilled. It was also shown that the signaling behavior of a covalent modification cycle can be quantitatively and, more importantly, qualitatively modified when this cycle is...

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Detalles Bibliográficos
Autor principal: Ventura, Alejandra C.
Publicado: 2013
Materias:
MAPK
Retroactivity
Signaling cascade
biochemistry
feedback mechanism
protein
article
enzyme stability
phosphorylation
signal transduction
theoretical model
Enzyme Stability
MAP Kinase Signaling System
Models, Theoretical
Phosphorylation
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00015342_v61_n1_p59_Sepulchre
http://hdl.handle.net/20.500.12110/paper_00015342_v61_n1_p59_Sepulchre
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00015342_v61_n1_p59_Sepulchre
record_format dspace
spelling paper:paper_00015342_v61_n1_p59_Sepulchre2023-06-08T14:20:52Z Intrinsic Feedbacks in MAPK Signaling Cascades Lead to Bistability and Oscillations Ventura, Alejandra C. MAPK Retroactivity Signaling cascade biochemistry feedback mechanism protein article enzyme stability phosphorylation signal transduction theoretical model Enzyme Stability MAP Kinase Signaling System Models, Theoretical Phosphorylation Previous studies have demonstrated that double phosphorylation of a protein can lead to bistability if some conditions are fulfilled. It was also shown that the signaling behavior of a covalent modification cycle can be quantitatively and, more importantly, qualitatively modified when this cycle is coupled to a signaling pathway as opposed to being isolated. This property was named retroactivity. These two results are studied together in this paper showing the existence of interesting phenomena-oscillations and bistability-in signaling cascades possessing at least one stage with a double-phosphorylation cycle as in MAPK cascades. © 2013 Springer Science+Business Media Dordrecht. Fil:Ventura, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00015342_v61_n1_p59_Sepulchre http://hdl.handle.net/20.500.12110/paper_00015342_v61_n1_p59_Sepulchre
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic MAPK
Retroactivity
Signaling cascade
biochemistry
feedback mechanism
protein
article
enzyme stability
phosphorylation
signal transduction
theoretical model
Enzyme Stability
MAP Kinase Signaling System
Models, Theoretical
Phosphorylation
spellingShingle MAPK
Retroactivity
Signaling cascade
biochemistry
feedback mechanism
protein
article
enzyme stability
phosphorylation
signal transduction
theoretical model
Enzyme Stability
MAP Kinase Signaling System
Models, Theoretical
Phosphorylation
Ventura, Alejandra C.
Intrinsic Feedbacks in MAPK Signaling Cascades Lead to Bistability and Oscillations
topic_facet MAPK
Retroactivity
Signaling cascade
biochemistry
feedback mechanism
protein
article
enzyme stability
phosphorylation
signal transduction
theoretical model
Enzyme Stability
MAP Kinase Signaling System
Models, Theoretical
Phosphorylation
description Previous studies have demonstrated that double phosphorylation of a protein can lead to bistability if some conditions are fulfilled. It was also shown that the signaling behavior of a covalent modification cycle can be quantitatively and, more importantly, qualitatively modified when this cycle is coupled to a signaling pathway as opposed to being isolated. This property was named retroactivity. These two results are studied together in this paper showing the existence of interesting phenomena-oscillations and bistability-in signaling cascades possessing at least one stage with a double-phosphorylation cycle as in MAPK cascades. © 2013 Springer Science+Business Media Dordrecht.
author Ventura, Alejandra C.
author_facet Ventura, Alejandra C.
author_sort Ventura, Alejandra C.
title Intrinsic Feedbacks in MAPK Signaling Cascades Lead to Bistability and Oscillations
title_short Intrinsic Feedbacks in MAPK Signaling Cascades Lead to Bistability and Oscillations
title_full Intrinsic Feedbacks in MAPK Signaling Cascades Lead to Bistability and Oscillations
title_fullStr Intrinsic Feedbacks in MAPK Signaling Cascades Lead to Bistability and Oscillations
title_full_unstemmed Intrinsic Feedbacks in MAPK Signaling Cascades Lead to Bistability and Oscillations
title_sort intrinsic feedbacks in mapk signaling cascades lead to bistability and oscillations
publishDate 2013
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00015342_v61_n1_p59_Sepulchre
http://hdl.handle.net/20.500.12110/paper_00015342_v61_n1_p59_Sepulchre
work_keys_str_mv AT venturaalejandrac intrinsicfeedbacksinmapksignalingcascadesleadtobistabilityandoscillations
_version_ 1768543302849658880

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