Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen

Abstract: Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and i...

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Autores principales: Toro-Urrego, Nicolás, Vesga-Jiménez, Diego Julián, Herrera, María Inés, Luaces, Juan Pablo, Capani, Francisco
Formato: Artículo
Lenguaje:Inglés
Publicado: Bentham Science Publishers 2020
Materias:
ESTROGENO
ISQUEMIA
LESION CEREBRAL
NEUROPROTECCION
ENCEFALOPATIAS
HIPOTERMIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/9869
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-9869
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ESTROGENO
ISQUEMIA
LESION CEREBRAL
NEUROPROTECCION
ENCEFALOPATIAS
HIPOTERMIA
spellingShingle ESTROGENO
ISQUEMIA
LESION CEREBRAL
NEUROPROTECCION
ENCEFALOPATIAS
HIPOTERMIA
Toro-Urrego, Nicolás
Vesga-Jiménez, Diego Julián
Herrera, María Inés
Luaces, Juan Pablo
Capani, Francisco
Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
topic_facet ESTROGENO
ISQUEMIA
LESION CEREBRAL
NEUROPROTECCION
ENCEFALOPATIAS
HIPOTERMIA
description Abstract: Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge of underlying mechanisms triggering these insults may help establish neuroprotective treatments. Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators exert several neuroprotective effects, including a decrease of reactive oxygen species, maintenance of cell viability, mitochondrial survival, among others. However, these strategies represent a traditional approach of targeting a single factor of pathology without satisfactory results. Hence, combined therapies, such as the administration of therapeutic hypothermia with a complementary neuroprotective agent, constitute a promising alternative. In this sense, the present review summarizes the underlying mechanisms of hypoxic-ischemic brain injury and compiles several neuroprotective strategies, including Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators, which represent putative agents for combined therapies with therapeutic hypothermia.
format Artículo
author Toro-Urrego, Nicolás
Vesga-Jiménez, Diego Julián
Herrera, María Inés
Luaces, Juan Pablo
Capani, Francisco
author_facet Toro-Urrego, Nicolás
Vesga-Jiménez, Diego Julián
Herrera, María Inés
Luaces, Juan Pablo
Capani, Francisco
author_sort Toro-Urrego, Nicolás
title Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
title_short Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
title_full Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
title_fullStr Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
title_full_unstemmed Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
title_sort neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
publisher Bentham Science Publishers
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/9869
work_keys_str_mv AT torourregonicolas neuroprotectiveroleofhypothermiainhypoxicischemicbraininjurycombinedtherapiesusingestrogen
AT vesgajimenezdiegojulian neuroprotectiveroleofhypothermiainhypoxicischemicbraininjurycombinedtherapiesusingestrogen
AT herreramariaines neuroprotectiveroleofhypothermiainhypoxicischemicbraininjurycombinedtherapiesusingestrogen
AT luacesjuanpablo neuroprotectiveroleofhypothermiainhypoxicischemicbraininjurycombinedtherapiesusingestrogen
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bdutipo_str Repositorios
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