Melatonin and mitochondrial dysfunction in the central nervous system
Abstract: Cell death and survival are critical events for neurodegeneration, mitochondria being increasingly seen as important determinants of both. Mitochondrial dysfunction is considered a major causative factor in Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). I...
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Formato: | Artículo |
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Elsevier
2019
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Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/1632 |
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I33-R139123456789-1632 |
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Universidad Católica Argentina |
institution_str |
I-33 |
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R-139 |
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Repositorio Institucional de la Universidad Católica Argentina (UCA) |
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Inglés Inglés |
topic |
MELATONINA MITOCONDRIAS SISTEMA NERVIOSO CENTRAL RADICALES LIBRES ENVEJECIMIENTO STRESS ENFERMEDAD DE ALZHEIMER ENFERMEDAD DE HUNTINGTON ENFERMEDAD DE PARKINSON |
spellingShingle |
MELATONINA MITOCONDRIAS SISTEMA NERVIOSO CENTRAL RADICALES LIBRES ENVEJECIMIENTO STRESS ENFERMEDAD DE ALZHEIMER ENFERMEDAD DE HUNTINGTON ENFERMEDAD DE PARKINSON Cardinali, Daniel Pedro Pagano, Eleonora S. Scacchi Bernasconi, Pablo A. Reynoso, Roxana Scacchi, Pablo Melatonin and mitochondrial dysfunction in the central nervous system |
topic_facet |
MELATONINA MITOCONDRIAS SISTEMA NERVIOSO CENTRAL RADICALES LIBRES ENVEJECIMIENTO STRESS ENFERMEDAD DE ALZHEIMER ENFERMEDAD DE HUNTINGTON ENFERMEDAD DE PARKINSON |
description |
Abstract: Cell death and survival are critical events for neurodegeneration, mitochondria being increasingly seen as important determinants of both. Mitochondrial dysfunction is considered a major causative factor in Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). Increased free radical generation, enhanced mitochondrial inducible nitric oxide (NO) synthase activity and NO production, and disrupted electron transport system and mitochondrial permeability transition, have all been involved in impaired mitochondrial function. Melatonin, the major secretory product of the pineal gland, is an antioxidant and an effective protector of mitochondrial bioenergetic function. Both in vitro and in vivo, melatonin was effective to prevent oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of AD, PD and HD. These effects are seen at doses 2-3 orders of magnitude higher than those required to affect sleep and circadian rhythms, both conspicuous targets of melatonin action. Melatonin is selectively taken up by mitochondria, a function not shared by other antioxidants. A limited number of clinical studies indicate that melatonin can improve sleep and circadian rhythm disruption in PD and AD patients. More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects which were employed in clinical trials in sleep-disturbed or depressed patients in doses considerably higher than those employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin in the range of 50-100 mg/day are needed to assess its therapeutic validity in neurodegenerative disorders. |
format |
Artículo |
author |
Cardinali, Daniel Pedro Pagano, Eleonora S. Scacchi Bernasconi, Pablo A. Reynoso, Roxana Scacchi, Pablo |
author_facet |
Cardinali, Daniel Pedro Pagano, Eleonora S. Scacchi Bernasconi, Pablo A. Reynoso, Roxana Scacchi, Pablo |
author_sort |
Cardinali, Daniel Pedro |
title |
Melatonin and mitochondrial dysfunction in the central nervous system |
title_short |
Melatonin and mitochondrial dysfunction in the central nervous system |
title_full |
Melatonin and mitochondrial dysfunction in the central nervous system |
title_fullStr |
Melatonin and mitochondrial dysfunction in the central nervous system |
title_full_unstemmed |
Melatonin and mitochondrial dysfunction in the central nervous system |
title_sort |
melatonin and mitochondrial dysfunction in the central nervous system |
publisher |
Elsevier |
publishDate |
2019 |
url |
https://repositorio.uca.edu.ar/handle/123456789/1632 |
work_keys_str_mv |
AT cardinalidanielpedro melatoninandmitochondrialdysfunctioninthecentralnervoussystem AT paganoeleonoras melatoninandmitochondrialdysfunctioninthecentralnervoussystem AT scacchibernasconipabloa melatoninandmitochondrialdysfunctioninthecentralnervoussystem AT reynosoroxana melatoninandmitochondrialdysfunctioninthecentralnervoussystem AT scacchipablo melatoninandmitochondrialdysfunctioninthecentralnervoussystem |
bdutipo_str |
Repositorios |
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1764820525756973058 |