Clinical relevance of stem cells in lung cancer

Abstract: Lung cancer is the major cause of cancer-related deaths worldwide, it has one of the lowest 5-year survival rate, mainly because it is diagnosed in the late stage of the disease. Lung cancer is classified into two groups, small cell lung cancer (SCLC) and non-SCLC (NSCLC). In turn, NSCLC i...

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Autores principales: Romeo, Horacio, Barreiro Arcos, María Laura
Formato: Artículo
Lenguaje:Inglés
Publicado: Baishideng 2024
Materias:
CANCER DE PULMON
CELULAS MADRE CANCEROSAS
BIOMARCADORES
QUIMIORRESISTENCIA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/18250
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-18250
record_format dspace
spelling I33-R139-123456789-182502024-06-10T19:52:58Z Clinical relevance of stem cells in lung cancer Romeo, Horacio Barreiro Arcos, María Laura CANCER DE PULMON CELULAS MADRE CANCEROSAS BIOMARCADORES QUIMIORRESISTENCIA Abstract: Lung cancer is the major cause of cancer-related deaths worldwide, it has one of the lowest 5-year survival rate, mainly because it is diagnosed in the late stage of the disease. Lung cancer is classified into two groups, small cell lung cancer (SCLC) and non-SCLC (NSCLC). In turn, NSCLC is categorized into three distinct cell subtypes: Adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. NSCLC is the most common lung cancer, accounting for 85% of all lung cancers. Treatment for lung cancer is linked to the cell type and stage of the disease, involving chemotherapy, radiation therapy, and surgery. Despite improvements in therapeutic treatments, lung cancer patients show high rates of recurrence, metastasis, and resistance to chemotherapy. Lung stem cells (SCs) are undifferentiated cells capable of self-renewal and proliferation, are resistant to chemotherapy and radiotherapy and, due to their properties, could be involved in the development and progression of lung cancer. The presence of SCs in the lung tissue could be the reason why lung cancer is difficult to treat. The identification of lung cancer stem cells biomarkers is of interest for precision medicine using new therapeutic agents directed against these cell populations. In this review, we present the current knowledge on lung SCs and discuss their functional role in the initiation and progression of lung cancer, as well as their role in tumor resistance to chemotherapy. 2024-06-07T18:31:12Z 2024-06-07T18:31:12Z 2023 Artículo Romeo, H. E., Barreiro Arcos, M. L. Clinical relevance of stem cells in lung cancer [En línea]. World J Stem Cells, 2023; 15 (6): 576-588. Disponible en línea: https://repositorio.uca.edu.ar/handle/123456789/18250 1948-0210 (online) https://repositorio.uca.edu.ar/handle/123456789/18250 10.4252/wjsc.v15.i6.576 eng Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Baishideng Instituto de Investigaciones Biomédicas
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CANCER DE PULMON
CELULAS MADRE CANCEROSAS
BIOMARCADORES
QUIMIORRESISTENCIA
spellingShingle CANCER DE PULMON
CELULAS MADRE CANCEROSAS
BIOMARCADORES
QUIMIORRESISTENCIA
Romeo, Horacio
Barreiro Arcos, María Laura
Clinical relevance of stem cells in lung cancer
topic_facet CANCER DE PULMON
CELULAS MADRE CANCEROSAS
BIOMARCADORES
QUIMIORRESISTENCIA
description Abstract: Lung cancer is the major cause of cancer-related deaths worldwide, it has one of the lowest 5-year survival rate, mainly because it is diagnosed in the late stage of the disease. Lung cancer is classified into two groups, small cell lung cancer (SCLC) and non-SCLC (NSCLC). In turn, NSCLC is categorized into three distinct cell subtypes: Adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. NSCLC is the most common lung cancer, accounting for 85% of all lung cancers. Treatment for lung cancer is linked to the cell type and stage of the disease, involving chemotherapy, radiation therapy, and surgery. Despite improvements in therapeutic treatments, lung cancer patients show high rates of recurrence, metastasis, and resistance to chemotherapy. Lung stem cells (SCs) are undifferentiated cells capable of self-renewal and proliferation, are resistant to chemotherapy and radiotherapy and, due to their properties, could be involved in the development and progression of lung cancer. The presence of SCs in the lung tissue could be the reason why lung cancer is difficult to treat. The identification of lung cancer stem cells biomarkers is of interest for precision medicine using new therapeutic agents directed against these cell populations. In this review, we present the current knowledge on lung SCs and discuss their functional role in the initiation and progression of lung cancer, as well as their role in tumor resistance to chemotherapy.
format Artículo
author Romeo, Horacio
Barreiro Arcos, María Laura
author_facet Romeo, Horacio
Barreiro Arcos, María Laura
author_sort Romeo, Horacio
title Clinical relevance of stem cells in lung cancer
title_short Clinical relevance of stem cells in lung cancer
title_full Clinical relevance of stem cells in lung cancer
title_fullStr Clinical relevance of stem cells in lung cancer
title_full_unstemmed Clinical relevance of stem cells in lung cancer
title_sort clinical relevance of stem cells in lung cancer
publisher Baishideng
publishDate 2024
url https://repositorio.uca.edu.ar/handle/123456789/18250
work_keys_str_mv AT romeohoracio clinicalrelevanceofstemcellsinlungcancer
AT barreiroarcosmarialaura clinicalrelevanceofstemcellsinlungcancer
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