Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases

Abstract: The cholinergic system plays an essential role in brain development, physiology, and pathophysiology. Herein, we review how specific alterations in this system, through genetic mutations or abnormal receptor function, can lead to aberrant neural circuitry that triggers disease. The review...

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Autores principales: Vallés, Ana Sofía, Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: Multidisciplinary Digital Publishing Institute 2023
Materias:
ENFERMEDAD DE ALZHEIMER
ENFERMEDAD DE PARKINSON
EPILEPSIA
ESPECTRO DE ESQUIZOFRENIA
ADICCIONES
SALUD
ENFERMEDADES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/16987
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-16987
record_format dspace
spelling I33-R139-123456789-169872023-08-26T05:04:26Z Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases Vallés, Ana Sofía Barrantes, Francisco José ENFERMEDAD DE ALZHEIMER ENFERMEDAD DE PARKINSON EPILEPSIA ESPECTRO DE ESQUIZOFRENIA ADICCIONES SALUD ENFERMEDADES Abstract: The cholinergic system plays an essential role in brain development, physiology, and pathophysiology. Herein, we review how specific alterations in this system, through genetic mutations or abnormal receptor function, can lead to aberrant neural circuitry that triggers disease. The review focuses on the nicotinic acetylcholine receptor (nAChR) and its role in addiction and in neurodegenerative and neuropsychiatric diseases and epilepsy. Cholinergic dysfunction is associated with inflammatory processes mainly through the involvement of α7 nAChRs expressed in brain and in peripheral immune cells. Evidence suggests that these neuroinflammatory processes trigger and aggravate pathological states. We discuss the preclinical evidence demonstrating the therapeutic potential of nAChR ligands in Alzheimer disease, Parkinson disease, schizophrenia spectrum disorders, and in autosomal dominant sleep-related hypermotor epilepsy. PubMed and Google Scholar bibliographic databases were searched with the keywords indicated below. 2023-08-25T13:15:27Z 2023-08-25T13:15:27Z 2023 Artículo Vallés, A. S., Barrantes, F. J. Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases [en línea]. Cells. 2023, 12(16). doi:10.3390/cells12162051. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16987 2073-4409 (online) https://repositorio.uca.edu.ar/handle/123456789/16987 10.3390/cells12162051 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Multidisciplinary Digital Publishing Institute Cells.Vol.12, No.16, 2023
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ENFERMEDAD DE ALZHEIMER
ENFERMEDAD DE PARKINSON
EPILEPSIA
ESPECTRO DE ESQUIZOFRENIA
ADICCIONES
SALUD
ENFERMEDADES
spellingShingle ENFERMEDAD DE ALZHEIMER
ENFERMEDAD DE PARKINSON
EPILEPSIA
ESPECTRO DE ESQUIZOFRENIA
ADICCIONES
SALUD
ENFERMEDADES
Vallés, Ana Sofía
Barrantes, Francisco José
Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
topic_facet ENFERMEDAD DE ALZHEIMER
ENFERMEDAD DE PARKINSON
EPILEPSIA
ESPECTRO DE ESQUIZOFRENIA
ADICCIONES
SALUD
ENFERMEDADES
description Abstract: The cholinergic system plays an essential role in brain development, physiology, and pathophysiology. Herein, we review how specific alterations in this system, through genetic mutations or abnormal receptor function, can lead to aberrant neural circuitry that triggers disease. The review focuses on the nicotinic acetylcholine receptor (nAChR) and its role in addiction and in neurodegenerative and neuropsychiatric diseases and epilepsy. Cholinergic dysfunction is associated with inflammatory processes mainly through the involvement of α7 nAChRs expressed in brain and in peripheral immune cells. Evidence suggests that these neuroinflammatory processes trigger and aggravate pathological states. We discuss the preclinical evidence demonstrating the therapeutic potential of nAChR ligands in Alzheimer disease, Parkinson disease, schizophrenia spectrum disorders, and in autosomal dominant sleep-related hypermotor epilepsy. PubMed and Google Scholar bibliographic databases were searched with the keywords indicated below.
format Artículo
author Vallés, Ana Sofía
Barrantes, Francisco José
author_facet Vallés, Ana Sofía
Barrantes, Francisco José
author_sort Vallés, Ana Sofía
title Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
title_short Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
title_full Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
title_fullStr Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
title_full_unstemmed Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
title_sort nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
publisher Multidisciplinary Digital Publishing Institute
publishDate 2023
url https://repositorio.uca.edu.ar/handle/123456789/16987
work_keys_str_mv AT vallesanasofia nicotinicacetylcholinereceptordysfunctioninaddictionandinsomeneurodegenerativeandneuropsychiatricdiseases
AT barrantesfranciscojose nicotinicacetylcholinereceptordysfunctioninaddictionandinsomeneurodegenerativeandneuropsychiatricdiseases
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