Risk factors for drug-resistant epilepsy in adult patients

Abstract: Introduction: Drug-resistant epilepsy occurs in about 30% of epilepsy patients. It has been suggestedthat etiology or seizure type would increase the risk of pharmacoresistance. This study aims to comparethe characteristics of patients with drug-sensitive epilepsy with patients with drug-r...

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Autores principales: Lagger, Ignacio, Garino, Eliana, Martínez, Oscar, Knorre, Eduardo, Ernst, Glenda, Burgueño, Adriana Laura
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2023
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Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/16411
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spelling I33-R139-123456789-164112023-11-23T17:46:23Z Risk factors for drug-resistant epilepsy in adult patients Factores de riesgo de epilepsia farmacorresistente en pacientes adultos Lagger, Ignacio Garino, Eliana Martínez, Oscar Knorre, Eduardo Ernst, Glenda Burgueño, Adriana Laura ANTICONVULSIVOS EPILEPSIA FARMACORRESISTENTE FARMACORRESISTENCIA EPILEPSIA REFRACTARIA PACIENTES Abstract: Introduction: Drug-resistant epilepsy occurs in about 30% of epilepsy patients. It has been suggestedthat etiology or seizure type would increase the risk of pharmacoresistance. This study aims to comparethe characteristics of patients with drug-sensitive epilepsy with patients with drug-resistant epilepsy toidentify risk factors.Patient and methods: A multicentric cohort study was conducted between 2019 and 2022. We includedpatients >18 years-old with epilepsy but excluded psychogenic non-epileptic seizures and less than 2years of follow-up.Results: We included 128 patients, of whom 46 had drug-resistance epilepsy, and 82 responding tomedication. Both groups showed similar characteristics. Febrile seizures (OR: 7.25), focal epilepsy (OR:2.4), focal seizures with loss of consciousness (OR: 2.36), structural etiology (OR: 2.2) and abnormal MRI(OR: 4.6) were significant risk factors for drug-resistance epilepsy.Conclusion: Following other studies, we observed that factors such as epilepsy type, seizure type, struc-tural etiology, abnormal MRI, and febrile seizure increased the risk for drug-resistance epilepsy, in ourpopulation. Resumen: Introducción: La epilepsia farmacorresistente se presenta en aproximadamente 30% de los pacientes quepadecen epilepsia. Se ha sugerido que la etiología o el tipo de crisis aumentarían el riesgo de farma-corresistencia. El objetivo de este estudio es comparar las características de los pacientes con epilepsiafármacosensible con las de los pacientes con epilepsia farmacorresistente para identificar los factores deriesgo.Pacientes y métodos: Se realizó un estudio de cohorte multicéntrico entre 2019 y 2022. Se incluyeronpacientes >18 a˜nos con epilepsia pero se excluyeron las crisis psicógenas no epilépticas y menos de dosa˜nos de seguimiento.Resultados: Se incluyeron 128 pacientes, de los cuales 46 tenían epilepsia farmacorresistente y 82respondían a la medicación. Ambos grupos mostraron características similares. Las crisis febriles (OR:7,25), la epilepsia focal (OR: 2,4), las crisis focales con pérdida de conciencia (OR: 2,36), la etiologíaestructural (OR: 2,2) y la resonancia magnética anormal (OR: 4,6) fueron factores de riesgo significativosde epilepsia farmacorresistente. 2023-05-29T16:41:09Z 2023-05-29T16:41:09Z 2023 Artículo Lagger, I. et al. Risk factors for drug-resistant epilepsy in adult patients [en línea]. Postprint de artículo publicado en Medicina Clínica. 2023. doi: 10.1016/j.medcli.2023.03.006. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16411 0025-7753 (impreso) 1578-8989 (online) https://repositorio.uca.edu.ar/handle/123456789/16411 10.1016/j.medcli.2023.03.006 37045668 eng Acceso abierto (12 meses de embargo) http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Postprint de artículo publicado en Medicina Clínica. 2023
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic ANTICONVULSIVOS
EPILEPSIA FARMACORRESISTENTE
FARMACORRESISTENCIA
EPILEPSIA REFRACTARIA
PACIENTES
spellingShingle ANTICONVULSIVOS
EPILEPSIA FARMACORRESISTENTE
FARMACORRESISTENCIA
EPILEPSIA REFRACTARIA
PACIENTES
Lagger, Ignacio
Garino, Eliana
Martínez, Oscar
Knorre, Eduardo
Ernst, Glenda
Burgueño, Adriana Laura
Risk factors for drug-resistant epilepsy in adult patients
topic_facet ANTICONVULSIVOS
EPILEPSIA FARMACORRESISTENTE
FARMACORRESISTENCIA
EPILEPSIA REFRACTARIA
PACIENTES
description Abstract: Introduction: Drug-resistant epilepsy occurs in about 30% of epilepsy patients. It has been suggestedthat etiology or seizure type would increase the risk of pharmacoresistance. This study aims to comparethe characteristics of patients with drug-sensitive epilepsy with patients with drug-resistant epilepsy toidentify risk factors.Patient and methods: A multicentric cohort study was conducted between 2019 and 2022. We includedpatients >18 years-old with epilepsy but excluded psychogenic non-epileptic seizures and less than 2years of follow-up.Results: We included 128 patients, of whom 46 had drug-resistance epilepsy, and 82 responding tomedication. Both groups showed similar characteristics. Febrile seizures (OR: 7.25), focal epilepsy (OR:2.4), focal seizures with loss of consciousness (OR: 2.36), structural etiology (OR: 2.2) and abnormal MRI(OR: 4.6) were significant risk factors for drug-resistance epilepsy.Conclusion: Following other studies, we observed that factors such as epilepsy type, seizure type, struc-tural etiology, abnormal MRI, and febrile seizure increased the risk for drug-resistance epilepsy, in ourpopulation.
format Artículo
author Lagger, Ignacio
Garino, Eliana
Martínez, Oscar
Knorre, Eduardo
Ernst, Glenda
Burgueño, Adriana Laura
author_facet Lagger, Ignacio
Garino, Eliana
Martínez, Oscar
Knorre, Eduardo
Ernst, Glenda
Burgueño, Adriana Laura
author_sort Lagger, Ignacio
title Risk factors for drug-resistant epilepsy in adult patients
title_short Risk factors for drug-resistant epilepsy in adult patients
title_full Risk factors for drug-resistant epilepsy in adult patients
title_fullStr Risk factors for drug-resistant epilepsy in adult patients
title_full_unstemmed Risk factors for drug-resistant epilepsy in adult patients
title_sort risk factors for drug-resistant epilepsy in adult patients
publisher Elsevier
publishDate 2023
url https://repositorio.uca.edu.ar/handle/123456789/16411
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