Homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases

Abstract: Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels involved in the modulation of essential brain functions such as memory, learning, and attention. Homomeric α7 nAChR, formed exclusively by five identical α7 subunits, is involved in rapid synaptic transm...

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Autores principales: Borroni, María Virginia, Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: Multidisciplinary Digital Publishing Institute 2022
Materias:
SISTEMA NERVIOSO CENTRAL
ENFERMEDADES
RECEPTOR DE ACETILCOLINA
NEUROTRANSMISIÓN COLINÉRGICA
ESPINA DENDRÍTICA
PROTEÍNA RECEPTORA DE NEUROTRANSMISORES
NICOTÍNICO
SINAPTOPATÍA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14577
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14577
record_format dspace
spelling I33-R139-123456789-145772023-11-23T17:05:56Z Homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases Borroni, María Virginia Barrantes, Francisco José SISTEMA NERVIOSO CENTRAL ENFERMEDADES RECEPTOR DE ACETILCOLINA NEUROTRANSMISIÓN COLINÉRGICA ESPINA DENDRÍTICA PROTEÍNA RECEPTORA DE NEUROTRANSMISORES NICOTÍNICO SINAPTOPATÍA Abstract: Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels involved in the modulation of essential brain functions such as memory, learning, and attention. Homomeric α7 nAChR, formed exclusively by five identical α7 subunits, is involved in rapid synaptic transmission, whereas the heteromeric oligomers composed of α7 in combination with β subunits display metabotropic properties and operate in slower time frames. At the cellular level, the activation of nAChRs allows the entry of Na+ and Ca2+; the two cations depolarize the membrane and trigger diverse cellular signals, depending on the type of nAChR pentamer and neurons involved, the location of the intervening cells, and the networks of which these neuronal cells form part. These features make the α7 nAChR a central player in neurotransmission, metabolically associated Ca2+-mediated signaling, and modulation of diverse fundamental processes operated by other neurotransmitters in the brain. Due to its ubiquitous distribution and the multiple functions it displays in the brain, the α7 nAChR is associated with a variety of neurological and neuropsychiatric disorders whose exact etiopathogenic mechanisms are still elusive. 2022-07-28T15:50:56Z 2022-07-28T15:50:56Z 2021 Artículo Borroni, M.V., Barrantes, F.J. Homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases [en línea]. Membranes. 2021, 11 (9). doi: https://doi.org/10.3390/membranas11090664. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14577 2077-0375 (online) https://repositorio.uca.edu.ar/handle/123456789/14577 10.3390/membranas11090664 34564481 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Multidisciplinary Digital Publishing Institute Membranes Vol.11, No.9, 2021
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic SISTEMA NERVIOSO CENTRAL
ENFERMEDADES
RECEPTOR DE ACETILCOLINA
NEUROTRANSMISIÓN COLINÉRGICA
ESPINA DENDRÍTICA
PROTEÍNA RECEPTORA DE NEUROTRANSMISORES
NICOTÍNICO
SINAPTOPATÍA
spellingShingle SISTEMA NERVIOSO CENTRAL
ENFERMEDADES
RECEPTOR DE ACETILCOLINA
NEUROTRANSMISIÓN COLINÉRGICA
ESPINA DENDRÍTICA
PROTEÍNA RECEPTORA DE NEUROTRANSMISORES
NICOTÍNICO
SINAPTOPATÍA
Borroni, María Virginia
Barrantes, Francisco José
Homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases
topic_facet SISTEMA NERVIOSO CENTRAL
ENFERMEDADES
RECEPTOR DE ACETILCOLINA
NEUROTRANSMISIÓN COLINÉRGICA
ESPINA DENDRÍTICA
PROTEÍNA RECEPTORA DE NEUROTRANSMISORES
NICOTÍNICO
SINAPTOPATÍA
description Abstract: Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels involved in the modulation of essential brain functions such as memory, learning, and attention. Homomeric α7 nAChR, formed exclusively by five identical α7 subunits, is involved in rapid synaptic transmission, whereas the heteromeric oligomers composed of α7 in combination with β subunits display metabotropic properties and operate in slower time frames. At the cellular level, the activation of nAChRs allows the entry of Na+ and Ca2+; the two cations depolarize the membrane and trigger diverse cellular signals, depending on the type of nAChR pentamer and neurons involved, the location of the intervening cells, and the networks of which these neuronal cells form part. These features make the α7 nAChR a central player in neurotransmission, metabolically associated Ca2+-mediated signaling, and modulation of diverse fundamental processes operated by other neurotransmitters in the brain. Due to its ubiquitous distribution and the multiple functions it displays in the brain, the α7 nAChR is associated with a variety of neurological and neuropsychiatric disorders whose exact etiopathogenic mechanisms are still elusive.
format Artículo
author Borroni, María Virginia
Barrantes, Francisco José
author_facet Borroni, María Virginia
Barrantes, Francisco José
author_sort Borroni, María Virginia
title Homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases
title_short Homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases
title_full Homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases
title_fullStr Homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases
title_full_unstemmed Homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases
title_sort homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases
publisher Multidisciplinary Digital Publishing Institute
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14577
work_keys_str_mv AT borronimariavirginia homomericandheteromerica7nicotinicacetylcholinereceptorsinhealthandsomecentralnervoussystemdiseases
AT barrantesfranciscojose homomericandheteromerica7nicotinicacetylcholinereceptorsinhealthandsomecentralnervoussystemdiseases
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