COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent

Abstract: SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, belongs to a broad family of coronaviruses that also affect humans. SARS-CoV-2 infection usually leads to bilateral atypical pneumonia with significant impairment of respiratory function. However, the infectious capacity o...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Menéndez, Sebastián García, Martín Giménez, Virna Margarita, Holick, Michael F., Barrantes, Francisco José, Manucha, Walter
Formato: Artículo
Lenguaje:Inglés
Publicado: Elservier 2022
Materias:
COVID-19
NEURODEGENERACION
NEUROINFLAMACION
VITAMINA D
PANDEMIA
VITAMINAS
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14431
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14431
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic COVID-19
NEURODEGENERACION
NEUROINFLAMACION
VITAMINA D
PANDEMIA
VITAMINAS
spellingShingle COVID-19
NEURODEGENERACION
NEUROINFLAMACION
VITAMINA D
PANDEMIA
VITAMINAS
Menéndez, Sebastián García
Martín Giménez, Virna Margarita
Holick, Michael F.
Barrantes, Francisco José
Manucha, Walter
COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent
topic_facet COVID-19
NEURODEGENERACION
NEUROINFLAMACION
VITAMINA D
PANDEMIA
VITAMINAS
description Abstract: SARS-CoV-2, the etiological agent of the current COVID-19 pandemic, belongs to a broad family of coronaviruses that also affect humans. SARS-CoV-2 infection usually leads to bilateral atypical pneumonia with significant impairment of respiratory function. However, the infectious capacity of SARS-CoV-2 is not limited to the respiratory system, but may also affect other vital organs such as the brain. The central nervous system is vulnerable to cell damage via direct invasion or indirect virus-related effects leading to a neuroinflammatory response, processes possibly associated with a decrease in the activity of angiotensin II converting enzyme (ACE2), the canonical cell-surface receptor for SARS-CoV-2. This enzyme regulates neuroprotective and neuroimmunomodulatory functions and can neutralize both inflammation and oxidative stress generated at the cellular level. Furthermore, there is evidence of an association between vitamin D deficiency and predisposition to the development of severe forms of COVID-19, with its possible neurological and neuropsychiatric sequelae: vitamin D has the ability to down-modulate the effects of neuroinflammatory cytokines, among other anti-inflammatory/immunomodulatory effects, thus attenuating harmful consequences of COVID-19. This review critically analyzes current evidence supporting the notion that vitamin D may act as a neuroprotective and neuroreparative agent against the neurological sequelae of COVID-19.
format Artículo
author Menéndez, Sebastián García
Martín Giménez, Virna Margarita
Holick, Michael F.
Barrantes, Francisco José
Manucha, Walter
author_facet Menéndez, Sebastián García
Martín Giménez, Virna Margarita
Holick, Michael F.
Barrantes, Francisco José
Manucha, Walter
author_sort Menéndez, Sebastián García
title COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent
title_short COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent
title_full COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent
title_fullStr COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent
title_full_unstemmed COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent
title_sort covid-19 and neurological sequelae: vitamin d as a possible neuroprotective and/or neuroreparative agent
publisher Elservier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14431
work_keys_str_mv AT menendezsebastiangarcia covid19andneurologicalsequelaevitamindasapossibleneuroprotectiveandorneuroreparativeagent
AT martingimenezvirnamargarita covid19andneurologicalsequelaevitamindasapossibleneuroprotectiveandorneuroreparativeagent
AT holickmichaelf covid19andneurologicalsequelaevitamindasapossibleneuroprotectiveandorneuroreparativeagent
AT barrantesfranciscojose covid19andneurologicalsequelaevitamindasapossibleneuroprotectiveandorneuroreparativeagent
AT manuchawalter covid19andneurologicalsequelaevitamindasapossibleneuroprotectiveandorneuroreparativeagent
bdutipo_str Repositorios
_version_ 1764820523465834502

Ejemplares similares