Control-oriented model with intra-patient variations for an artificial pancreas

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"In this work, a low-order model designed for glucose regulation in Type 1 Diabetes Mellitus (T1DM) is obtained from the UVA/Padova metabolic simulator. It captures not only the nonlinear behavior of the glucose-insulin system, but also intrapatient variations related to daily insulin sensit...

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Autores principales: Moscoso-Vásquez, Marcela, Colmegna, Patricio, Rosales, Nicolás, Garelli, Fabricio, Sánchez-Peña, Ricardo
Formato: Artículos de Publicaciones Periódicas acceptedVersion
Lenguaje:Inglés
Publicado: 2020
Materias:
ORGANOS ARTIFICIALES
PANCREAS
DIABETES
INSULINA
CONTROL ROBUSTO
GLUCOSA
Acceso en línea:http://ri.itba.edu.ar/handle/123456789/1906
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-1906
record_format dspace
spelling I32-R138-123456789-19062022-12-07T13:06:23Z Control-oriented model with intra-patient variations for an artificial pancreas Moscoso-Vásquez, Marcela Colmegna, Patricio Rosales, Nicolás Garelli, Fabricio Sánchez-Peña, Ricardo ORGANOS ARTIFICIALES PANCREAS DIABETES INSULINA CONTROL ROBUSTO GLUCOSA "In this work, a low-order model designed for glucose regulation in Type 1 Diabetes Mellitus (T1DM) is obtained from the UVA/Padova metabolic simulator. It captures not only the nonlinear behavior of the glucose-insulin system, but also intrapatient variations related to daily insulin sensitivity (SI) changes. To overcome the large inter-subject variability, the model can also be personalized based on a priori patient information. The structure is amenable for linear parameter varying (LPV) controller design, and represents the dynamics from the subcutaneous insulin input to the subcutaneous glucose output. The eficacy of this model is evaluated in comparison with a previous control-oriented model which in turn is an improvement of previous models. Both models are compared in terms of their open- and closed-loop differences with respect to the UVA/Padova model. The proposed model outperforms previous T1DM control oriented models, which could potentially lead to more robust and reliable controllers for glycemia regulation." 2020-03-18T12:47:10Z 2020-03-18T12:47:10Z 2020 Artículos de Publicaciones Periódicas info:eu-repo/semantics/acceptedVersion http://ri.itba.edu.ar/handle/123456789/1906 en info:eu-repo/grantAgreement/Fundación Nuria/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/CONICET/PIP/112-201501-00837/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/grantAgreement/JDRF/APF/2-APF-2019-373-A-N/US. Nueva York. NY info:eu-repo/grantAgreement/Fundación Cellex/SP. Barcelona info:eu-repo/grantAgreement/ANPCyT/PICT/2017-3211/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/semantics/altIdentifier/doi10.1109/JBHI.2020.2969389 application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic ORGANOS ARTIFICIALES
PANCREAS
DIABETES
INSULINA
CONTROL ROBUSTO
GLUCOSA
spellingShingle ORGANOS ARTIFICIALES
PANCREAS
DIABETES
INSULINA
CONTROL ROBUSTO
GLUCOSA
Moscoso-Vásquez, Marcela
Colmegna, Patricio
Rosales, Nicolás
Garelli, Fabricio
Sánchez-Peña, Ricardo
Control-oriented model with intra-patient variations for an artificial pancreas
topic_facet ORGANOS ARTIFICIALES
PANCREAS
DIABETES
INSULINA
CONTROL ROBUSTO
GLUCOSA
description "In this work, a low-order model designed for glucose regulation in Type 1 Diabetes Mellitus (T1DM) is obtained from the UVA/Padova metabolic simulator. It captures not only the nonlinear behavior of the glucose-insulin system, but also intrapatient variations related to daily insulin sensitivity (SI) changes. To overcome the large inter-subject variability, the model can also be personalized based on a priori patient information. The structure is amenable for linear parameter varying (LPV) controller design, and represents the dynamics from the subcutaneous insulin input to the subcutaneous glucose output. The eficacy of this model is evaluated in comparison with a previous control-oriented model which in turn is an improvement of previous models. Both models are compared in terms of their open- and closed-loop differences with respect to the UVA/Padova model. The proposed model outperforms previous T1DM control oriented models, which could potentially lead to more robust and reliable controllers for glycemia regulation."
format Artículos de Publicaciones Periódicas
acceptedVersion
author Moscoso-Vásquez, Marcela
Colmegna, Patricio
Rosales, Nicolás
Garelli, Fabricio
Sánchez-Peña, Ricardo
author_facet Moscoso-Vásquez, Marcela
Colmegna, Patricio
Rosales, Nicolás
Garelli, Fabricio
Sánchez-Peña, Ricardo
author_sort Moscoso-Vásquez, Marcela
title Control-oriented model with intra-patient variations for an artificial pancreas
title_short Control-oriented model with intra-patient variations for an artificial pancreas
title_full Control-oriented model with intra-patient variations for an artificial pancreas
title_fullStr Control-oriented model with intra-patient variations for an artificial pancreas
title_full_unstemmed Control-oriented model with intra-patient variations for an artificial pancreas
title_sort control-oriented model with intra-patient variations for an artificial pancreas
publishDate 2020
url http://ri.itba.edu.ar/handle/123456789/1906
work_keys_str_mv AT moscosovasquezmarcela controlorientedmodelwithintrapatientvariationsforanartificialpancreas
AT colmegnapatricio controlorientedmodelwithintrapatientvariationsforanartificialpancreas
AT rosalesnicolas controlorientedmodelwithintrapatientvariationsforanartificialpancreas
AT garellifabricio controlorientedmodelwithintrapatientvariationsforanartificialpancreas
AT sanchezpenaricardo controlorientedmodelwithintrapatientvariationsforanartificialpancreas
_version_ 1765660693065891840

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