A monoclonal antibody against p53 cross-reacts with processing bodies

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The p53 tumor suppressor protein is an important regulator of cell proliferation and apoptosis. p53 can be found in the nucleus and in the cytosol, and the subcellular location is key to control p53 function. In this work, we found that a widely used monoclonal antibody against p53, termed Pab 1801...

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Detalles Bibliográficos
Autores principales: Thomas, M.G., Luchelli, L., Pascual, M., Gottifredi, V., Boccaccio, G.L.
Formato: Artículo publishedVersion
Publicado: 2012
Materias:
cell marker
cycloheximide
decapping enzyme 1a
decapping enzyme 1b
decapping enzyme 2
epitope
exoribonuclease
exoribonuclease 1
messenger RNA
monoclonal antibody
pantropic antibody 1801
protein 4ET
protein Hedls
protein p53
protein p54
small interfering RNA
unclassified drug
TP53 protein, human
animal cell
animal tissue
article
cell component
cell disruption
cell line
cell stimulation
cell strain HCT116
cellular distribution
concentration (parameters)
controlled study
cross reaction
dissolution
Drosophila
embryo
fetus
gene control
gene silencing
genetic transfection
human
human cell
image analysis
immunohistochemistry
intracellular signaling
nonhuman
polysome
processing body
protein analysis
protein localization
rat
upregulation
animal
antibody specificity
chemistry
cytoplasm
immunology
metabolism
Sprague Dawley rat
tumor cell line
Rattus
Rodentia
Animals
Antibodies, Monoclonal, Murine-Derived
Antibody Specificity
Cell Line, Tumor
Cytoplasm
Epitopes
Humans
Immunohistochemistry
Rats
Rats, Sprague-Dawley
Tumor Suppressor Protein p53
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19326203_v7_n5_p_Thomas
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_19326203_v7_n5_p_Thomas_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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