CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response

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DNA damage triggers a phosphorylation-based signaling cascade known as the DNA damage response. p19INK4d, a member of the INK4 family of CDK4/6 inhibitors, has been reported to participate in the DNA damage response promoting DNA repair and cell survival. Here, we provide mechanistic insight into th...

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Autores principales:	Marazita, M.C., Florencia Ogara, M., Sonzogni, S.V., Martí, M., Dusetti, N.J., Pignataro, O.P., Cánepa, E.T.
Formato:	Artículo publishedVersion
Publicado:	2012
Materias:	amyloid beta protein ATM protein ATR protein checkpoint kinase 1 checkpoint kinase 2 cisplatin cyclic AMP dependent protein kinase cyclin dependent kinase 2 cyclin dependent kinase 4 cyclin dependent kinase 6 cyclin dependent kinase inhibitor 2D phosphate p 32 serine threonine CDK2 protein, human DNA article cell nucleus cell survival conformational transition controlled study DNA damage DNA repair point mutation protein phosphorylation signal transduction ultraviolet radiation cell cycle cell line cell strain HEK293 drug effect gene expression regulation genetics human metabolism mutation phosphorylation protein transport radiation exposure Amyloid beta-Peptides Cell Cycle Cell Line Cell Survival Cisplatin Cyclic AMP-Dependent Protein Kinases Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase Inhibitor p19 DNA Damage DNA Repair Gene Expression Regulation HEK293 Cells Humans Mutation Phosphorylation Protein Transport Signal Transduction Ultraviolet Rays
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_19326203_v7_n4_p_Marazita https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_19326203_v7_n4_p_Marazita_oai
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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