Insights on glucocorticoid receptor activity modulation through the binding of rigid steroids

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Background: The glucocorticoid receptor (GR) is a transcription factor that regulates gene expression in a ligand-dependent fashion. This modular protein is one of the major pharmacological targets due to its involvement in both cause and treatment of many human diseases. Intense efforts have been m...

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Autores principales:	Presman, D.M., Alvarez, L.D., Levi, V., Eduardo, S., Digman, M.A., Martí, M.A., Veleiro, A.S., Burton, G., Pecci, A.
Formato:	Artículo publishedVersion
Publicado:	2010
Materias:	21 hemisuccinate 6,19 epoxyprogesterone 21 hydroxy 6,19 epoxyprogesterone dexamethasone glucocorticoid receptor glucocorticoid receptor antagonist mifepristone nuclear receptor coactivator 2 unclassified drug DNA steroid article binding affinity cell assay cell culture cell strain BHK cell strain COS7 cell strain L 929 cell type computer model conformational transition controlled study dissociation DNA drug complex drug mechanism drug receptor binding genetic transfection in vitro study in vivo study incubation time ligand binding modulation molecular dynamics oligomerization protein DNA binding protein DNA interaction protein function steroid binding structure activity relation animal cell line cell strain COS1 Cercopithecus chemical structure dimerization gel mobility shift assay immunoprecipitation metabolism protein binding Animals Cell Line Cercopithecus aethiops COS Cells Dimerization Electrophoretic Mobility Shift Assay Immunoprecipitation Models, Molecular Molecular Dynamics Simulation Protein Binding Receptors, Glucocorticoid Steroids
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_19326203_v5_n10_p_Presman https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_19326203_v5_n10_p_Presman_oai
Aporte de:	Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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