Anticoagulant activity of a unique sulfated pyranosic (1→3)-β-L- arabinan through direct interaction with thrombin

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A highly sulfated 3-linked β-arabinan (Ab1) with arabinose in the pyranose form was obtained from green seaweed Codium vermilara (Bryopsidales). It comprised major amounts of units sulfated on C-2 and C-4 and constitutes the first polysaccharide of this type isolated in the pure form and fully chara...

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Detalles Bibliográficos
Autores principales: Fernández, P.V., Quintana, I., Cerezo, A.S., Caramelo, J.J., Pol-Fachin, L., Verli, H., Estevez, J.M., Ciancia, M.
Formato: Artículo publishedVersion
Publicado: 2013
Materias:
Amino acid residues
Anticoagulant activities
Antithrombin
Arabinans
Catalytic sites
CD spectra
Conformational change
Direct interactions
Glycosaminoglycans
Green seaweed
Heparin cofactor
Ligand binding
Model compound
Octasaccharide
Pyranose
Sulfate groups
Sulfated polysaccharides
Thrombin inhibition
Amino acids
Coagulation
Computer simulation
Fluorescence spectroscopy
Oligosaccharides
Polysaccharides
Seaweed
Enzymes
algal extract
amino acid
arabinose
carbohydrate
heparin cofactor II
oligosaccharide
polysaccharide
protein
sulfated pyranosic beta arabinan
thrombin
unclassified drug
anticoagulation
article
blood clotting test
catalysis
circular dichroism
conformational transition
drug mechanism
drug structure
fluorescence spectroscopy
ligand binding
molecular dynamics
nonhuman
priority journal
protein modification
protein protein interaction
seaweed
simulation
Animals
Anticoagulants
Biophysics
Blood Coagulation
Carbohydrate Conformation
Cattle
Cell Wall
Circular Dichroism
Electrophoresis
Gas Chromatography-Mass Spectrometry
Humans
Kinetics
Magnetic Resonance Spectroscopy
Methylation
Models, Chemical
Molecular Conformation
Protein Binding
Pyrans
Spectroscopy, Fourier Transform Infrared
Thrombin
Caulerpales
Codium vermilara
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219258_v288_n1_p223_Fernandez
https://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&d=paper_00219258_v288_n1_p223_Fernandez_oai
Aporte de:
Repositorio Digital de la Universidad de Buenos Aires (UBA) de Universidad de Buenos Aires

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